不同剂量左氧氟沙星治疗淋病合并非淋菌性尿道炎临床效果.doc

不同剂量左氧氟沙星治疗淋病合并非淋菌性尿道炎的临床效果 　　【摘要】目的：对淋病合并非淋菌性尿道炎患者给予不同剂量左氧氟沙星实施治疗的效果进行分析探究。方法：选取在我院接受治疗的80例淋病合并非淋菌性尿道炎患者作为本次研究对象，根据随机数字表法将其平均分为大剂量组与小剂量组两组，分别给予0.5g/次、0.1g/次左氧氟沙星治疗，对比分析两组临床疗效、治疗后2周淋球菌筛查结果以及并发症情况。结果：两组患者均未见不良反应，大剂量组总有效率为95.00%，小剂量组为62.50%，两组相比试验组明显较高，差异有统计学意义（χ2=15.7404，P=0.00038）。大剂量组研究对象的淋球菌检测阳性率（2.50%）与小剂量组淋球菌检测阳性率（35.00%）相比明显较低，差异有统计学意义（χ2=13.8667，P=0.0002）。大剂量组研究对象的并发症发生率（5.00%）与对照组（37.50%）相比明显较低，差异有统计学意义（χ2=10.7563，P=0.00104）。结论：对淋病伴非淋菌性尿道炎患者采用大剂量左氧氟沙星治疗的效果显著，复查结果较好，药物抗菌性较强，并发症较少发生，具有较高的安全性，值得推广 【关键词】不同剂量；左氧氟沙星；淋病；非淋菌性尿道炎；临床效果 【Abstract】Objectives： To analyze the treatment efficacy of different levofloxacin dosages in the treatment of gonorrhea and non-gonococcal urethritis. Methods： Eighty patients with gonorrhea and non-gonococcal urethritis were randomly divided into two groups. Patients in high dose group and low dose group were respectively treated with 0.5 g and 0.1 g levofloxacin. Clinical efficacy， Neisseria gonorrhoeae screening results 2 weeks after treatment and complications were compared in the two groups. Results： No adverse reactions were found in the two groups. The overall response rate in high dose group （95.00%） was significantly higher than that in low dose group （62.50%） （χ2=15.7404， P=0.00038）. Neisseria gonorrhoeae positive rate （2.50%） in high dose group was obviously lower than that in low dose group （35.00%）， with statistically significant difference （χ2=13.8667， P=0.0002）. The incidence of complications in high dose group （5.00%） was obviously lower than that in control group （37.50%）， with statistically significant difference （χ2= 10.7563， P=0.00104）. Conclusion： High-dose levofloxacin is effective in treating gonorrhea and non-gonococcal urethritis， with good recheck outcome， strong antibacterial property， fewer complications and high security， which is worth popularizing. 【Key words】Different dosages； Levofloxacin； Gonorrhea； Non-gonococcal urethritis； Clinical efficacy 【中图分类号】R759.2【文献标志码】A 近几年来，临床上淋病的发病人数不断增多，该疾病主要