人非小细胞肺癌中蛋白激酶C_的表达及细胞凋亡及预后关系的研究.pdf

# 404 # 2004 10 7 5 Chin J Lung Cancer, October 2004, Vol.7, No. 5 ## C BÑ 程玺 周清华 王允 张尚福 刘关键 成娘 = CB Ñ( PKC-BÑ) LSABTUNEL 119 32 PKC-BÑ ( 1) NSCLC PKC-B Ñ ( 82.27%) ( 62.85%) ( 50.47%) ( P 0.05) , PKC-B Ñ( P 0.05) NSCLC ( 5.27%) ( 15.84%) ( P 0.05) ( 2) NSCLC PKC-B Ñ ( P 0. 05) NSCLC pTNM ( P 0.05) ,( P 0. 05) ( 3) PKC-BÑ ( P 0.01) (4) PKC-BÑ5 ( 7.37%) (37.06%) ( P 0.01) 5 ( 39. 24%) ( 6. 14%)( P 0. 01) PKC-B Ñ , = CBÑ( PKC-BÑ) TUNEL LSAB = 734. 2 Relationship between protein kinase CBÑ ( PKC-BÑ) expression, apoptosis and prognosis in patients with non- small cell lung cancer CH EN G X i, ZH O U Qinghua , WAN G Yun, ZHA N G Shangf u, L I U Guanj ian, CHEN G N iang. K ey L ab rat ry f L ung Cancer M lecular Bi l gy f Sichuan Pr vince and Cancer Center , West China H sp ital , Sichuan University , Chengdu, S ichuan 610041, P . R . China C rresp nding auth r: ZH O U Qinghua, E-mail : z h uqh@ mail . sc. cninf . net = Abstract Objecti e To investigate the relationship between expression of PKC-BÑ, apoptosisand progno- sis of non-small cell lung cancer (NSCLC) . Methods The expression of PKC-BÑ and apoptosis index (AI) were detected in 119 human NSCLC tissues and paracancerous tissues by LSAB and TUNEL, with 32 benign pulmonary disease tissues as control. Results ( 1) The expression of PKC-BÑ ( 82. 27%)