植物多酚抗肥胖作用研究进展_高航.pdf

334 2014, Vol.35, No.21 食品科学 ※专题论述 植物多酚抗肥胖作用的研究进展 高 航，徐 虹* （北京工商大学食品添加剂与配料北京高校工程研究中心，食品风味化学北京市重点实验室，北京 100048 ） 摘  要：植物多酚是一类广泛存在于植物体内的次生代谢产物，具有抗癌、抗氧化、抗菌、抗病毒等生物活性。随 着肥胖发生率的急速增加，抗肥胖药物或功能性食品的研究成为了热点。植物多酚类化合物抗肥胖效果显著，近年 来其抗肥胖机理也得到了进一步的阐明，本文对植物多酚在调节代谢酶活性、刺激机体产热、调节机体信号和肠道 微生物菌群方面的抗肥胖研究进展进行综述。 关键词：植物多酚；抗肥胖；机理 Progress in Understanding Anti-obesity Effects of Plant Polyphenols * GAO Hang, XU Hong (Beijing Key Laboratory of Flavor Chemistry, Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, Beijing Technology and Business University, Beijing 100048, China) Abstract: Plant polyphenols, a class of natural secondary metabolites widely presented in plants, have anti-cancer, anti- oxidant, anti-bacterial, anti-virus and other bioactivities. In recent years, the development of anti-obesity functional foods or drugs has become a hot topic due to the increasing obesity rate all over the world. Currently, many researchers have reported that plant polyphenols show significant anti-obesity effects, and the mechanisms have been revealed gradually. This paper reviews the recent progress in understanding the anti-obesity effects of plant polyphenols through modulating metabolic enzyme activities, stimulating thermogenesis and regulating the signaling pathways and intestinal microbial flora in the body. Key words: plant polyphenol; anti-obesity; mechanism 中图分类号：TS201.4 文献标志码：A 文章编号：1002-6630 （2014 ）21-0334-05 doi:10.7506/spkx1002-6630-201421063 肥胖已成为全球最主要的公共健康问题之一，其发 世界范围内长期使用。但是，欧洲药品管理局又先后停 生的根本原因是能量的摄入与输出不平衡，导致体内脂