胶原基硬脑膜研究进展.pdf

35 卷第 16 期 西 部 皮 革 Vol.35 No.16 西部皮革 第 35 卷 2013 年8 月 WESTLEATHER Aug.2013 胶原基硬脑膜的研究进展 1 1，2* 1，2 倪娜 ，但年华 ，但卫华 （1. 四川大学制革清洁技术国家工程实验室，四川成都610065 ；2. 四川大学生物医学工程技术研究 中心，四川成都610065） 摘 要：胶原基硬脑膜替代材料 能够在颅脑手术 中用以修复硬脑膜缺损 ，并有效诱导修复组织和重建 硬脑膜 。本文综述 了异种生物膜、脱细胞真皮基质以及提取胶原三类硬脑膜材料的相关研究和临床应 用情况，总结了这些人工硬脑膜的优缺点，展望了硬脑膜替代材料 未来的发展趋势和发展方 向。 关键词：胶原；人工硬脑膜；修复；进展 中图分类号：R318.08 文献标识码：A 文章编号：1671-1602 （2013）16-0008-05 Research Progress on Collagen-based Dura Matter 1 1,2 1,2 NI Na , DAN Nian-hua , DAN Wei-hua (1. National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu 610065, China; 2. The Research Center of Biomedicine Engineering of Sichuan University, Chengdu 610065, China) Abstract: Collagen-based artificial dura matter can be used to repair dural defects during craniocerebral operations, and is beneficial to triggering the reconstruction of the tissue and dura matter. In this paper we briefly overview the research progress and current situation of corresponding clinical application of three types of collagen -based dura matter repair materials, i.e. heterogeneous biomembrane, acellular dermal matrix and extracted collagen materials, and their advantages and disadvantages. Finally, the prospect of development trend of dural repair materials is made. Key words: collagen; artificial dura matter; repair; progress