跌打扭伤灵酊的药效学研究.pdfVIP

第 14 卷第 8 期 中国实验方剂学杂志 Vol. 14 ,No. 8 2008 年 8 月 Chinese Journal of Experimental Traditional Medical Formulae Aug. ,2008 跌打扭伤灵酊的药效学研究 刘 　元 ,宋志钊 ,李星宇 ,文志云 (广西中医药研究院 ,广西 南宁 　530022) 　　[摘要] 　目的:观察跌打扭伤灵酊的主要药效学作用 。方法 :采用佐剂致大鼠关节炎 、蛋清致大鼠足跖肿胀及棉球致大鼠 肉芽组织增生 、重物撞击致小鼠足跖部外伤性瘀血 、热板致小鼠疼痛等模型 ,观察跌打扭伤灵酊的药效学作用 。结果 :跌打扭 伤灵酊局部用药能明显抑制佐剂致大鼠关节炎 、对蛋清致大鼠足趾肿胀 ,有明显抑制作用 ,对棉球致肉芽组织增生有明显抑制 作用 ,并有显著的镇痛作用 。结论 :跌打扭伤灵酊具有抗炎 、活血散瘀 、镇痛作用 。 [ 关键词] 　跌打扭伤灵酊 ;佐剂性关节炎 ;抗炎 ;活血散瘀 ;镇痛 ( ) [ 中图分类号] 　R2855 　　[文献标识码] 　B 　　[文章编号] 2008 The Pharmacological Effects of Dieda Niushang Ling Tincture LIU Yuan , SONG Zhizhao ,LI Xingyu , WEN Zhiyun ( Guangxi Institute for Chinese Medicine Pharmaceutical Science ,Nanning 530022 , China) [ Abstract ] 　Objective :To observe the pharmacological effects of Dieda Niushang Ling Tincture. Methods :Using the model of the adjuvant induced arthritis in rats ,the egg white induced paw edema in rats ,the cotton cause granulation tissue hyperplasia in rats ,the weights collision induced foot traumatic bleeding in mice , hot plate induced pain in mice ,to observe the pharmacological role of Dieda Niushang Ling Tincture. Result : The partial use of Diedaniushangling tincture could significantly inhibit the adjuvant induced arthritis in rats , speeded up the absorption of traumatic congestion ,had clear antiinflammatory and analgesic effect. Conclusions : The Dieda Niushang Ling Tincture had the pharmacological effects of antirheumatic , antiinflammation , promo