氟非尼酮抗器官纤维化的作用与机制.PDF

中南大学学报（医学版） 2015, 40(2) htt p:// 208 J Cent South Univ (Med Sci) DOI:10.11817/j.issn.1672-7347.2015.02.016 /xbwk/fi leup/PDF/201502208.pdf 氟非尼酮抗器官纤维化的作用及机制 马虹 ，彭张哲，胡高云，陶立坚1 1 2 1 ( 中南大学 1. 湘雅医院肾内科，长沙 410008；2. 药学院，长沙 410013) [摘要]器官纤维化可发生于不同的组织器官，其发病率高、危害性大，尚缺乏有效的治疗药物。近年发现的新 型抗纤维化小分子化合物——氟非尼酮，为纤维化疾病的治疗带来了希望。氟非尼酮可以通过抗炎症反应、抗氧化 应激、抗细胞凋亡、抑制肌成纤维细胞的活化与增殖、促进细胞外基质降解及调节信号转导等多种途径，起到抗器 官纤维化的作用，明显减轻肾、肝及肺的纤维化程度。 [关键词] 器官纤维化；氟非尼酮；抗纤维化；肾；肝；肺 Effect and mechanism of fluorofenidone on organ fibrosis 1 1 2 1 MA Hong , PENG Zhangzhe , HU Gaoyun , TAO Lijian (1. Department of Nephrology, Xiangya Hospital, Changsha 410008; 2. School of Pharmaceutical Science, Central South University, Changsha 410013, China) ABSTRACT Fibrosis can occur in diff erent organs with high incidence rate and great danger. It still lacks eff ective drugs for prevention of fi brosis. Fluorofenidone is a newly developed drug with anti-fi brotic activity, which provides a new hope for treating the progressive fi brotic diseases. Recent studies have shown that fl uorofenidone is a multifunctional small molecule with anti-infl ammatory, antioxidative and anti-apoptotic eff ects. It can inhibit the activation and proliferation of myofi broblasts, promote the degradation of extracellular matrix and regulate the cellular signal transmission. Fluorofenidone can