2型糖尿病颈动脉粥样硬化和BDNF、VEGF的关系.doc

2型糖尿病颈动脉粥样硬化与BDNF、VEGF的关系 邱世超，任建功*，罗 晖，胡雪剑，侯园花 兰州大学第二医院糖尿病2科，兰州 730030 [收稿日期] 2014-04-17 [接受日期] 2014-05-19 [作者简介] 邱世超，硕士生.E-mail：quishichao@126.com *通信作者（Corresponding author）.Tel: 0931-8943526,E-mail:ren-jg@ [摘要] 目的 探讨血清脑源性神经营养因子（BDNF）、血管内皮生长因子（VEGF）与2型糖尿病（T2DM）颈动脉粥样硬化的关系。方法 收集兰州大学第二医院糖尿病2科收治住院的T2DM患者120例，依据颈动脉彩色多普勒超声显像分为合并颈动脉粥样硬化组64例和非颈动脉粥样硬化组56例。另收集同期体检中心健康体检者60例为对照。收集患者临床资料，并使用ELISA法测定血清BDNF 、VEGF浓度。结果 健康对照组、非颈动脉粥样硬化组、合并颈动脉粥样硬化组血清BDNF[(9.97±2.59)、(6.88±3.10)、（5.62±3.41）ng/mL]水平逐渐降低，差异有统计学意义（P＜0.05）；各组血清VEGF[(49.29±20.23)、(61.29±22.05)、（71.34±20.30）pg/mL]水平逐渐升高，差异具有统计学意义（P＜0.05）。结论 T2DM合并颈动脉粥样硬化患者血清BDNF水平降低、VEGF水平升高，提示血清低浓度BDNF及高浓度VEGF共同参与颈动脉粥样硬化的发生及发展。 [关键词] 2型糖尿病；颈动脉粥样硬化；脑源性神经营养因子；内皮细胞生长因子； [中文分类号] R587.2 文献标识码：A Relationship of the serum level of BDNF and VEGF with the carotid atherosclerosis in type 2 diabetes mellitus QIU Shi-chao, REN Jian-gong*, LUO Hui, HU Xue-jian, HOU Yuan-hua Department 2 of Diabetes, The Second Affiliated Hospital of Lanzhou University, Lanzhou 730050, Gansu, China 【Abstract】Objective To investigate the relationship between brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor（VEGF）with the carotid atherosclerosis in type 2 diabetes mellitus(T2DM). Methods A total of 120 T2DM patients were assigned to non carotid atherosclerosis group( n=56) and the carotid atherosclerosis group( n=64) by carotid artery ultrasound detection. 60 healthy controls were recruited from health check-up populations.Clinical data was collected,?and?the level of BDNF,?VEGF were determined by ELISA?.Results The level of BDNF (9.97±2.59),(6.88±3.10),（5.62±3.41）ng/mL of health check-up populations, non carotid atherosclerosis group,the carotid atherosclerosis group was gradually decreased (P＜0.05); The level of VEGF (49.29±20.23), (61.29±22.05),（71.34±20.30）pg/mL of the there groups was gradually increased (P＜0.05).Conclusions The level of BDNF is significantly decreased and the VEGF is significantly i