1259例住院患者微量白蛋白尿患病率与危险因素分析.doc

1259例住院患者微量白蛋白尿患病率及危险因素分析 王慧芳1Δ 原理2Δ 原爱红3 王亚坤3 傅鹏3* 蒋晓峰3* 1. 同济大学附属同济医院大华门诊部内科， 上海 200065 2. 上海市中西医结合医院急诊内科， 上海 200082 3. 同济大学附属同济医院肾内科， 上海 200065 [作者简介] E-mail： ； 原理，硕士，主治医师 E-mail126.com； ） *共同通信作者（Co-corresponding authors）E-mail：fupeng1966@ E-mail:jxf@163.com 【摘要】 目的 探讨住院患者微量白蛋白尿（microalbuminuriaMAU）的患病率及其相关危险因素。方法 选取2012年同济大学附属同济医院检测过尿微量白蛋白的1259例住院患者，根据尿微量白蛋白水平分为MAU组及正常白蛋白尿（NAU）组，并统计两组患者的临床特征。结果 住院患者MAU的患病率为27.9%。MAU组的年龄以及糖尿病、高血压的患病率高于NAU组（P0.01）。以年龄、性别、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、糖尿病、高血压、糖尿病合并高血压为自变量，以为因变量，年龄、糖尿病、高血压、糖尿病合并高血压与存在相关性多因素Logistic回归分析表明年龄、糖尿病同为MAU的独立危险因素，高龄（80岁，OR 1.668，95% CI 1.185～2.348）、糖尿病（OR 1.718，95% CI 1.334～2.211）使MAU的风险升高。结论 住院患者MAU与年龄、糖尿病密切相关。因此，严格控制血糖，及时干预治疗，有助于延缓糖尿病肾病、心血管疾病的发生发展。 【关键词】 微量白蛋白尿，危险因素，患病率[Abstract] Objective To evaluate the prevalence and risk factors of microalbuminuria (MAU) in hospitalized patients. Methods 1259 hospitalized patients with detected urinary microalbumin in the year of 2012 were recruited in Tongji Hospital of Tongji University. They were divided into two groups according to the level of urinary microalbumin. 907 cases were included in normal albuminuria (NAU) group, 352 cases were in microalbuminuria group. Statistical analysis of clinical data was made in the two groups. Results Microalbuminuria prevalence of hospitalized patients was 27.9%. The age in MAU group was elder than NAU group (P0.01), and the prevalence of type 2 diabetes mellitus and hypertension in MAU group was higher than NAU group (P0.01). The age, gender, TG, TC, LDL-C, HDL-C, type 2 diabetes, hypertension and type 2 diabetes+hypertension served as independent variables, and MAU as a dependent variable for univariate analysis. Results showed age, type 2 diabetes , hypertension and type 2 diabetes+hypertension were closely related to MAU. Further multivariate analysis with logistic regression revealed that age and type 2 diabetes were independent risk factors of MAU. Advanced