NY-ESO-1抗原和肿瘤免疫治疗进展.PDF

ACTA ACADEM IAE MEDICINAE SIN ICAE # # NY-ESO-1 彭吉润, 冷希圣 , 100044 : /: 010 : lengxisheng@ ku h1edu1cn : NY-ESO-1-, , , NY-ESO-1 T , NY-ESO-1, NY-ESO-1 : ; NY-ESO-1; -; : R73013 : A : 1000-503X ( 2008) 04-037 1-07 DOI: 10 13881/j1issn11000-503X 120081041003 NY-ESO-1 and Cancer Immunotherapy PENG J-i run, LENG X-i sheng Center ofH e atobiliary Surgery, PekingUniversity Peo lepsHos ita,l Beijing 100044, China C orres ond ing author: LENG X i-sheng T el/Fax: 010 E-mail: lengx isheng@ ku h1edu1cn ABSTRACT: NY-ESO-1 is an mi ortantm em ber of cancer-testis antigen fam ily and isw idely distributed am ong m any cancer ty es1 As a tum or-s ecific antigen w ith the strongest mi m unogenicity so far identified, it can induce s ontaneous antibody and T-cell res onses in atientsw ith NY-ESO-1- ositive tumors1 Therefore, it has been a good vaccine cand idate in the mi m unothera y againstm any m alignancies1 This article rev iews the re- cent research advances in NY-ESO-1 and its relevant vaccines1 Key ords: cancer mi munothera y; NY-ESO-1; cancer-testis antigen; cancer vaccine A cta A cad M ed S in, 2008, 30(4): 37 1- 377 , , , - ( cancer-testis antigen, CT ) NY-ESO-1 CT : ( 1) [ 2, 3] NY-ESO-1 Chen cDNA ;