α-硫辛酸治疗糖尿病周围神经病变的临床疗效与机制.PDF

临床与病理杂志 2014, 34(3) J Clin Path ol R e s 307 DOI:10.11714/j.issn.2095-6959.2014.03.017 /articles/360 α-硫辛酸治疗糖尿病周围神经病变的临床疗效及机制 郑茂，荆春艳 综述 叶山东 审校 (安徽医科大学附属安徽省立医院内分泌科，合肥 230001) [摘　要] 糖尿病神经病变的发生是多因素的，氧化应激是其发病的中心环节。 α -硫辛酸是一种强有力的抗 氧化剂，将其单独或与其他药物联合应用治疗糖尿病周围神经病变，取得了较好的临床疗效，并 且具有很好的安全性和耐受性。其保护糖尿病周围神经病变的机制包括增加神经血流、改善神经 + + 传导速度、增加神经 Na -K -ATP 酶活性、抑制脂质过氧化、抗炎、保护血管内皮功能等。 [关键词] 糖尿病；糖尿病周围神经病变；α-硫辛酸；临床疗效；疗效机制 Therapeutic effect and mechanisms of alpha lipoic acid in the treatment of diabetic peripheral neuropathy ZHENG Mao, JING Chunyan, YE Shandong (Department of Endocrinology, Anhui Provincial Hospital Affiliated with Anhui Medical University, Hefei 230001, China) Abstract Diabetic neuropathy is a multiple-factorial disorder. Oxidative stress is a critical factor in the development of diabetic perpheral neupropahy (DPN). As a powerful antioxidant, alpha lipoic acid (ALA) has been used alone or combined with other drugs to treat DPN with good safety and tolerability. The protective mechanisms of ALA in treatment of DPN are involved in increase of endoneurial blood flow and the Na+ + -K ATPase activity in nerve, improvement of nerve conduction velocity, inhibition of lipid peroxidation, resistance of inflammation and protection of endothelial function, etc. Key words diabetes; diabetic peripheral neuropathy; alpha lipoic acid; clinical ecacy; therapeutic mechanism 糖 尿 病 周 围 神 经 病 变 ( d i a b e t i c p e r i p h e r a l glycosylatio