生物信息学1陈润生2015.ppt

生物信息学现状和重要研究方向 陈润生 E-mail : crs@ runshengc@ Tel: 86-10Fax: 86-10 凌伦奖 E-mail : ling@ Tel: 86-10 中国科学院生物物理研究所 北京朝阳区大屯路15号 FISH Different probes used to mark each chomosome Computer identifies probe and give chromosome a false color Trisomy 13Patau Syndrome Patau Syndrome Cleft lip and palate Extra fingers toes polydactylism Defects Heart Brain Kidney Most abort Live span 1 month 一. 什么是生物信息学？ Genome informatics is a scientific discipline that encompasses all aspects of genome information acquisition, processing, storage, distribution, analysis, and interpretation. 它是一个学科领域，包含着基因组信息的获取、处理、存储、分配 、分析和解释的所有方面。 (The U.S. Human Genome Project: The First Five Years FY 1991-1995, by NIH and DOE) 从美国的三个国家计划说起：曼哈顿计划；阿婆罗计划；人类基因组计划。 破译人类遗传密码就要读懂由30亿符号组成的100万页的“天书” A Draft Sequence of the Rice Genome (Oryza sativa L.?ssp. indica) Jun Yu,1,2,3,4 *Songnian Hu,1 *Jun Wang,1,2,5 *Gane Ka-Shu Wong,1,2,4 *Songgang Li,1,5 Bin Liu,1 Yajun Deng,1,6Li Dai,1 Yan Zhou,2,7 Xiuqing Zhang,1,3 Mengliang Cao,8 Jing Liu,2Jiandong Sun,1 Jiabin Tang,1,3 Yanjiong Chen,1,6Xiaobing Huang,1 Wei Lin,2 Chen Ye,1 Wei Tong,1 Lijuan Cong,1Jianing Geng,1 Yujun Han,1 Lin Li,1 Wei Li,1,9 Guangqiang Hu,1Xiangang Huang,1 Wenjie Li,1 Jian Li,1 Zhanwei Liu,1 Long Li,1Jianping Liu,1 Qiuhui Qi,1 Jinsong Liu,1 Li Li,1 Tao Li,1Xuegang Wang,1 Hong Lu,1 Tingting Wu,1 Miao Zhu,1Peixiang Ni,1 Hua Han,1 Wei Dong,1,3 Xiaoyu Ren,1Xiaoli Feng,1,3 Peng Cui,1 Xianran Li,1 Hao Wang,1 Xin Xu,1Wenxue Zhai,3 Zhao Xu,1 Jinsong Zhang,3 Sijie He,3Jianguo Zhang,1 Jichen Xu,3 Kunlin Zhang,1,5 Xianwu Zheng,3Jianhai Dong,2 Wanyong Zeng,3 Lin Tao,2 Jia Ye,2 Jun Tan,2Xide Ren,1 Xuewei Chen,3 Jun He,2 Daofeng Liu,3 Wei Tian,2,6Chaoguang Tian,1 Hongai Xia,1 Qiyu Bao,1 Gang Li,1Hui Gao,1 Ting Cao,1 Juan Wang,1 Wenming Zhao,1 Ping Li,3Wei Chen,1 Xudong Wang,3 Yong Zhang,1,5 Jianfei Hu,1,5Jing Wang,1,5 Song Liu,1 Jian Yang,1 Guangyu Zhang,1Yuqing