FT- IR光谱法研究TA9902抑制AB 1- 42.pdf

# 84 # Ch nese Journal of Pathophys ology 2006, 22( 1) : 84 - 87 [ ] 1000- 4718( 2006) 01- 00 84- 04 FT- IR TA9902 AB 1- 42 * 1, 2 1 1v 李光武 , 汪华侨 , 姚志彬 ( 1 , 510080; 2 , 230032) [ ] : TA9902 AB , AB : 1- 42 ( FT- IR) AB TA9902 : 1 700- 1 600 cm- 1 I , AB1- 4230 m n , B- 46153% ; AB1- 42 72 h, B- 65113% ,B- 1914% TA9902 AB B- 29104% ; AB 72 h , 1- 42 1- 42 TA9902 B ( 361 09% ) ,B- ( 57156% ) ,A- ( 2193% ) B B- , TA9902 A- - CH2 - CH AB1- 42 : TA9902 AB1- 42B- , AB1- 42, AB B- [ ] ; B ; , [ ] R363 [ ] A Inhibitory effect of TA9902 on amyloid B- peptide 1 - 42 aggregation by Fourier- transform infrared spectroscopy study 1, 2 1 1 LI Guang- wu , WANG Hua- q ao , YAO Zh - b n 1 2 ( Dep artment of A natomy , Zhongshan Med ical College, Sun Yat - sen University , Guangzhou 510080, China Instit ute of Ne u- robiology , A nhui Medical Univ ersity , Hef ei 230032, China) ABSTRACT] AIM: To nvest gate the mechan sm by w h ch TA9902 nh b ts the format on of amylo d B- pept