丁氏溃结灌肠液气药灌肠法治疗UC临床疗效评估.doc

丁氏溃结灌肠液气药灌肠法治疗UC临床疗效评估ayo评分及临床症状积分变化、血白细胞、C反应蛋白、血红蛋白、血白蛋白等指标的变化。结果：E2组和E3组患者治疗前后改良Mayo评分、临床症状积分比较，差异均有统计学意义（P0.05），未见明显并发症。结论：丁氏溃结灌肠液对于轻中度UC疗效确切，气药灌肠法用于控制近端病变是安全有效的 【关键词】 溃疡性结肠炎； 丁氏溃结灌肠液； 气药灌肠； 病变部位 Clinical Effect of Dingshikuijieguanchangye with Gas Enema in Ulcerative Colitis/TAN Yan-yan，FANG Jian，DING Yi-jiang，et al.//Medical Innovation of China，2016，13（35）：072-076 【Abstract】 Objective：To evaluate the clinical effect of Dingshikuijieguanchangye with Gas Enema in patients with ulcerative colitis（UC）.Method：Forty-eight outpatient clinic or hospital UC patients（patients information were from the inflammatory bowel disease clinic，department of colorectal diseases，the 3rd Affiliated hospital of Nanjing University of Chinese Medicine from April 2012 to September 2013） were enrolled in the case series study.All subjects were received endoscopy，whose lesions were mild and moderate degree，and accepted the gas enema with Dingshikuijieguanchangye.All patients were classified into two groups according to their location of lesions，E2 group（including patients whose lesions were at the distal of splenic flexure） and E3 group （including patients whose lesions were involved in the proximal part of or the whole intestine）.Patients were treated with Gas Enema with Dingshikuijieguanchangye.Clinical indicators included modified Mayo score，clinical symptom scores，blood leukocytes，C-reactive protein，hemoglobin，serum albumin，etc.Result：The modified Mayo score，the clinical symptom scores and ESR of two groups were changed statistically significant（P 　　2.1 主要疗效指标变化 治疗前后两组患改良Mayo评分，E2组与E3组评分变化差异均有统计学意义（P0.05），见表1 2.2 次要疗效指标变化 2.2.1 临床症状积分变化 两组黏液血便积分、腹泻积分、腹痛积分治疗前后自身比较，差异均有统计学意义（P0.05）。见表2～4 2.2.2 血液相关指标变化 E2组患者血沉改变差异有统计学意义（P0.05）。提示气药灌肠对近端病变疗效与远端近似，可以覆盖近端病变，对于可耐受灌肠治疗的患者是一种可选择的治疗方式 3.2 丁氏溃结灌肠液治疗溃疡性结肠炎 丁氏溃结灌肠液是国家级名老中医丁泽民教授的临床经验方，现为我院院内制剂（规格：250 mL/瓶；批准文号：苏药制字Z040001781），由金银花、地榆、白及、复方珠黄散（人工牛黄、珍珠粉、川贝母、煅炉甘石等）组成，具有清热化湿、去腐生肌的功效，临床使用数十年，疗效确切[8-9]。临床观察发现，丁氏溃结灌肠液保留灌肠后便血症状迅速得到改善，轻中度