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应激对同型半胱氨酸代谢的负性调节
Acta Physiologica Sinica, August 25, 2004, 56 (4): 521-524 521
: Acta Physiologica Sinica, June 25, 2004, 56 (3): 269-274
*
, 300050
: , (homocysteine, HCY)
, , - HCY ,
β (cystathionine beta-synthase, CBS) , RT-PCR Northern blot
CBS mRNA , ; CBS ,
, ; CBS mRNA (P0.05), 3
70.6% 5.9% 55.9% 4.3% , HCY , CBS
; HCY
: ; ; ; β
: Q418
Negative regulation of homocysteine metabolism by stress in rats
*
WU Shu-Qing, QIAN Ling-Jia
Institute of Hygiene and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050 , China
Abstract : To investigate the effect of stress on homocysteine metabolism in the rat and explore the mechanism as well as the key
regulatory link of stress-induced hyperhomocysteinemia, male Wistar rats were treated with restraint stress while control rats received
routine treatment. By HPLC-fluorometry, the homocysteine level in rat plasma was determined. Cystathionine beta-synthase (CBS)
activity in blood, heart, liver and kidney was measured
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