血管内皮对狗离体冠状动脉β肾上腺素受体激动剂反应性的影响.pdf

ActaPharmaeo[ogiea$inica 十 目 理学报 Influenceofendothelium on responsesofisolated dogcoronary artery to [3-adrenoceptoragonists TANG Zi—Lue!，W U Wen—Jian，XIONG Xiao—M ing (DepartmentofPharmacoloKy，H 一口 MedicalUniversity，Changsha410078，China) AIM ： To studY the role oftheendothelium adren0ceDtorson theendothelium ofcoronary inmediating theresponseofthecoronaryar— arteries have been characterized in dogs and teriesto adrenoceptoragonists． METHODS： pigs ’． Somereportedthata—adrenergicac— Endothelium intactanddenudeddogepicardial tivation caused m inimaIor no constriction in coronary artery ringswere used． The COn— pig coronary m ；．crocirculation ”‘． Nor— tractileresponseswererecorded onforcetrans— epinephrine (NE ) predominantly dilates ducerandapen recorder． RESULIS： Inall porcine coronary m icrovessels by 日 adreno— ringsegments，norepinephrine (NE)andiso— ceptor activation． So me failed to confirm proterenol (Iso) produced concentration— adez nooeptor—mediated responses via the dependentrelaxation in thepresence and ab— endothelium inthedog： andrabbitcoronary senceofphentolam ine． Endothelium—remoraI arteries ． Some reported enhanced relax decreased this relaxation and depressed the ationofdogcoronaryarteryto口adrenoceptor maximalresponse． Inhibition ofnitricoxide agonistsafterremovalofendothelialcells ． synthesisbyN 一nitro—L argininemethylester Thepresentstudywasto exploretheroleof Induced the same jnfluencesasendothelium— functional 13-adrenoceptor in dog coronary remova1． CoNCLUSIoN ： 3_adrenoceptor artery endothelium and the prohahle under— agonists produce relaxation of dog coronary lying mechanisms of endothelium dependent arterybyboth endothellum—dependentand in responses to adrenocept