归肾丸对PCOS不孕症患者着床窗期子宫内膜容受性影响.doc

归肾丸对PCOS不孕症患者着床窗期子宫内膜容受性影响 　　【摘要】 目的：观察分析归肾丸对PCOS不孕症患者着床窗期子宫内膜容受性的影响。方法：选取2013年1月-2015年6月本院收治的56例PCOS不孕患者作为研究对象，采用随机数表法将患者分为治疗Ⅰ组（n=28）和治疗Ⅱ组（n=28），治疗Ⅰ组给予氯米芬（CC）/绒毛膜促性腺激素（hCG）促排卵，治疗Ⅱ组给予归肾丸+CC/hCG促排卵，选择同期因男性不育或输卵管因素就诊的不孕症患者28例为对照组。观察各组患者植入窗期的子宫内膜厚度、类型，子宫内膜下螺旋动脉血流指数（PI）、阻力指数（RI），血清E2、P水平，子宫内膜LIF水平和妊娠情况。结果：治疗Ⅱ组患者的子宫内膜厚度、类型，子宫内膜下螺旋动脉血流指数、阻力指数，血清P水平，子宫内膜LIF水平和妊娠率均显著优于对照组和治疗Ⅰ组，差异均有统计学意义（P0.05）。结论：归肾丸可显著改善PCOS不孕症患者着床窗期子宫内膜容受性，进而提高临床妊娠率，具有临床推广价值 【关键词】 归肾丸； 多囊卵巢综合征； 着床； 子宫内膜容受性 【Abstract】 Objective：To research the effect of Guishen Pill in improving endometrial receptivity in infertility patients with polycystic ovarian syndrome.Method：A total of 56 patients with PCOS selected from January 2013 to June 2015 were randomly divided into two groups，28 cases in each groups.Group Ⅰ was given CC/hCG treatment while group Ⅱ was given Guishen Pill+CC/hCG treatment.Totally 28 women having problems of tubal who underwent artificial insemination were recruited as the control group and they received no drug therapy.Endometrial thickness and pattern，PI，RI，the levels of serum E2 and P，LIF level of endometrial and rate of pregnancy were compared between two groups.Result：Endometrial thickness and patter，PI，RI，the levels of serum E2 and P，LIF level of endometrial and rate of pregnancy in group Ⅱ were better than those of the control group and group Ⅰ（P0.05）.Conclusion：Guishen Pill is an effective to improve the endometrial receptivity in infertility patients with polycystic ovarian syndrome and it has clinical value. 【Key words】 Guishen Pill； Polycystic ovary syndrome； Nidation； Endometrial receptivity First-authors address：Xiaolan Peoples Hospital of Zhongshan City，Zhongshan 528415，China doi：10.3969/j.issn.1674-4985.2016.32.020 多囊卵巢?C合征（polycystic ovary syndrome，PCOS）是一种复杂代谢及内分泌异常引起的疾病，以慢性排卵障碍（排卵功能丧失或紊乱）和高雄激素血症为主要特征，且常伴有胰岛素抵抗，糖、脂代谢异常，临床上主要表现为不孕、月经紊乱、多毛及痤疮，是最常见的女性内分泌疾病，常发病于育龄妇女，发病率为6%～10%，占不排卵性不孕症的50%～70%[1-3]。目前临床上对于PCOS不孕症的治疗主要集中于促排卵人工助孕，但常规促排卵后妊娠率也仅为20%～30%，且妊娠后流产率高。一方面是