厚朴皮、叶、花水提物镇痛作用的比较研究详解.PDF

第36 卷第2 期 Vol.36 No.2 冈山大学学报( 自然科学版) 2015 年3 月 Mar. 2015 Journal of Jinggangshan University (Natural Science) 74 74 冈山大学学报( 自然科学版) 章编号：1674-8085(20 15)02-0074-04 厚朴皮、叶、花水提物镇痛作用的比较研究 * 郑丽娟，余晓珊，梁生林，黄玉双，黄宜财 (井冈山大学医学院，江西，吉安 343009) 摘 要：目的 探讨并比较厚朴皮、叶、花的镇痛作用。方法 采用热板法、醋酸扭体法致痛，观察高、低剂量 厚朴皮、叶、花水提物的镇痛作用。结果 厚朴干皮、根皮、枝皮、叶、花水提物高、低剂量对热板法所致小鼠 痛阈值无影响，与蒸馏水对照组和自身给药前比较差异无统计学意义(P 0.05)；厚朴干皮、根皮、枝皮、叶、花 水提物高、低剂量对醋酸所致扭体反应数均有明显 制作用，与蒸馏水对照组比较差异显著(P 0.01)，厚朴根皮、 枝皮、叶、花水提物高、低剂量组与厚朴干皮相对应剂量组比较差异无统计学意义(P 0.05) 。结论 厚朴干皮、 根皮、枝皮、叶、花水提物均具有镇痛作用， 厚朴根皮、枝皮、叶、花可以代替厚朴干皮用于镇痛。 关键词：厚朴皮、叶、花；水提物；镇痛；比较 中图分类号：R285.5 献标识码：A DOI:10.3969/j.issn.1674-8085.2015.02.017 COMPARATIVE STUDY ON THE ANALGESIC EFFECT OF WATER EXTRACTS OF MA GNOLIA OFFI CINALIS BARK, LEAF AND FLOWER * ZHENG Li-juan, YU Xiao-shan, LIANG Sheng-lin, HUANG Yu-shuang, HUANG Yi-cai (School of Medicine, Jinggangshan University, Jian, Jiangxi 343009, China) Abstract Objective: To investigate and compare the analgesic effect of Magnolia offi cinalis bark, leaf, flower in mice. Methods: Using the hot-plate and acetic acid writhing method to induce pain in mice, to observe the analgesic effect of high and low doses of water extracts of M. off icinalis bark, leaf and flower. Results: Water extracts of high and low doses of M. offi cinalis stem, root and branch bark, leaf, flower had no significant effect on the pain threshold caused by hot plate method compared with the distilled water control group and the data before the drugs administration (P 0.05), but it is reversed for that by acetic acid writhing method, and