太赫兹成像技术在肿瘤诊断方面的应用详解.PDF

肿瘤2012 年12 月第32 卷第12 期　TUM OR Vol. 32, December 2012　　 1039 DOI: 10.3781/j .issn.1000-7431.2012 .12 .016 Copyright© 2012 by TUM OR Review 综述 · 太赫兹成像技术在肿瘤诊断方面的应用 1, 2 1, 2 3 1, 2 何明霞 ，陈　涛 ，杨吉龙 ，刘嘉政 1. 天津大学精密测试技术及仪器国家重点实验室，天津　300072 ；2 . 天津大学太赫兹中心，天津　300072 ；3. 天 津医科大学附属肿瘤医院骨与软组织肿瘤科，天津　300060 [摘要]　太赫兹波介于微波和红外线之间，是一种新型的远红外相干辐射源。与微波、X 射线和核磁共振成像相比， 太赫兹成像技术具有分辨率高、对生物样品无损伤的特点，近年来在生物医学领域得到了广泛的应用与研究，特 别是在肿瘤诊断方面有着巨大的应用潜力。结合透射式和反射式太赫兹成像系统，本文总结了太赫兹成像技术在 皮肤基底细胞癌、乳腺癌、肝癌和宫颈癌等肿瘤诊断中的应用、取得的成果和亟待解决的问题，对这种新型的肿 瘤诊断方法的临床应用做了有益的探索。 [关键词]　肿瘤；诊断显象；光谱分析；无线电波；太赫兹波 [中图分类号]　R730.4 　　　　[文献标志码] A [文章编号]　1000-7431 (2012) 12-1039-04 The application of terahertz imaging in tumor diagnosis 1, 2 1, 2 3 1, 2 HE Ming-xia , CHEN Tao , YANG Ji-long , LIU Jia-zheng 1. State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, Tianjin 300072, China; 2. Terahertz Center, Tianjin University, Tianjin 300072, China; 3. Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China [A BST RA CT]　Terahertz wave is a new coherent far infrared source that spans the gap between microwave and infrared radiation. Compared with microwave, X-ray and NMR (nuclear magnetic resonance) imaging, terahertz imaging has the advantages of high resolution and no harm to biological samples, which has been comprehensively applied in biomedical fields in recent years, especially in cancer diagnosis. Combined with the terahertz imaging systems of transmission type and reflection type, a general review of its application in diagnosis of skin basal cell carcinoma, breast cancer, liver cancer and c