心脉隆注射液联合多巴胺治疗慢性心力衰竭的疗效观察详解.PDF

·796 · 现代药物与临床 Drugs Clinic 第 32 卷 第 5 期 2017 年 5 月 心脉隆注射液联合多巴胺治疗慢性心力衰竭的疗效观察 杨 宁，王恒亮，司定然 濮阳市油田总医院 心血管内科，河南 濮阳 457001 摘 要：目的 探讨心脉隆注射液联合多巴胺治疗慢性心力衰竭的临床疗效。方法 选取 2015 年 1 月—2016 年 2 月濮阳市 油田总医院收治的慢性心力衰竭患者 66 例，随机分为对照组和治疗组，每组各 33 例。对照组静脉滴注盐酸多巴胺注射液， 30 mg/次，1 次/d 。治疗组在对照组的治疗基础上静脉滴注心脉隆注射液，5～10 mg/kg 加入生理盐水 250 mL ，2 次/d 。两组 均连续治疗 14 d。观察两组的临床疗效，比较两组治疗前后爬楼梯阶数、左心室舒张末期内径（LVEDD ）、左心室收缩末期 内径（LVESD ）和左室射血分数（LVEF ）的变化情况。结果 治疗后，对照组和治疗组的总有效率分别为 75.76%、93.94%， 两组比较差异有统计学意义（P ＜0.05 ）。治疗后，两组患者爬楼梯阶数、LVEF 显著升高，LVEDD 、LVESD 显著降低，同组 治疗前后差异有统计学意义（P ＜0.05 ）；治疗后，治疗组爬楼梯阶数、LVEF 高于对照组，LVEDD 、LVESD 低于对照组， 两组比较差异具有统计学意义（P ＜0.05 ）。结论 心脉隆注射液联合多巴胺治疗慢性心力衰竭具有较好的临床疗效，可显著 改善患者的运动耐力和心功能相关指标，具有一定的临床推广应用价值。 关键词：心脉隆注射液；盐酸多巴胺注射液；慢性心力衰竭；左心室舒张末期内径；左心室收缩末期内径；左室射血分数 中图分类号：R972 文献标志码：A 文章编号：1674 - 5515(2017)05 - 0796 - 04 DOI: 10.7501/j.issn.1674-5515.2017.05.010 Clinical observation of Xinmailong Injection combined with dopamine in treatment of chronic heart failure YANG Ning, WANG Heng-liang, SI Ding-ran Department of Cardiovascular Internal Medicine, Puyang Oilfield General Hospital, Puyang 457001, China Abstract: Objective To investigate the curative effect of Xinmailong Injection combined with dopamine in treatment of chronic heart failure. Methods Patients (66 cases) with chronic heart failure in Puyang Oilfield General Hospital from January 2015 to February 2016 were randomly divided into control and treatment groups, and each group had 33 cases. Patients in the control group were iv administered with Dopamine Hydrochloride Injection, 30 mg/time, once daily. Patients in the treatment group were iv administered with Xinmailong Injection, 5 — 10 mg/kg added into 250 mL normal saline, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the changes of climb the stair