玳玳果黄酮滴丸对高脂血症大鼠的降血脂作用研究.PDF

玳玳果黄酮滴丸对高脂血症大鼠的降血脂作用研究 邱红鑫，陈丹* ，刘永静，吴晓青，任瑞琴，程清(福建中医药大学药学院，福州 350108) 摘要：目的 建立大鼠高血脂模型，观察玳玳果黄酮滴丸对高脂血症大鼠的降血脂作用。 方法 选用 SD 大鼠 60 只， ♂，10 只作为空白对照组，喂饲普通饲料，其余高脂饲料喂饲，建立高脂血症模型，测定用药前后血清中胆固醇(TC)、 甘油三脂(TG)、低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)的含量；同时取肝脏切片，HE 染色，观察玳玳果黄酮滴 丸的降血脂作用。结果 玳玳果黄酮滴丸各剂量组均能明显降低高血脂大鼠血清中 TC、TG 和 LDL-C 含量；能明显升高 大鼠血清中 HDL-C 含量。病理切片结果显示，玳玳果黄酮滴丸能够明显减轻肝脏的脂肪变性。结论 玳玳果黄酮滴丸对 大鼠高脂血症有明显的预防作用，并能够阻止高脂血症大鼠的肝脏脂肪变性。 关键词：玳玳果黄酮滴丸；降血脂作用；脂肪肝 中图分类号：R285.5 文献标志码：A 文章编号：1007-7693(2011)07-0597-05 Study on Antiatheroscloresis Effects of Daidai Flavones Dropping Pills on Hyperlipidemia Rats * QIU Hongxin, CHEN Dan , LIU Yongjing, WU Xiaoqing, REN Ruiqin, CHENG Qing(College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China) ABSTRACT: OBJECTIVE Establish the hyperlipidemia rats model to observe antiatheroscloresis effects of daidai flavones dropping pills on hyperlipidemia rat. METHODS Sixty SD rats were grouped randomly. Among them, 10 were in control group, fed with conventional forage, while others were fed with high fatty forage, establish the hyperlipidemia model. The content of cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C) and high-density lipoprotein (HDL-C) in serum were determined. Take the liver, HE dyeing, to study the role of the daidai flavones dropping pills on lower cholesterol in hyperlipidemia rats. RESULTS The dropping pills could significantly lower the high blood fat rats’ serum TC, TG and LDL-C content, could obviously increase the rats’ serum HDL-C content. Furthermore, fatty degeneration was eased by daidai flavones dropping pills according to the pathological result. CONCLUSION The dai