咔啉生物碱Beta-carboline alkaloids derived from the ascidian Synoicum sp.pdf

Bioorganic Medicinal Chemistry 20 (2012) 4082–4087 Contents lists available at SciVerse ScienceDirect Bioorganic Medicinal Chemistry journal homepage: www.else /locate/bmc Beta-carboline alkaloids derived from the ascidian Synoicum sp. Tae Hyung Won a, Ju-eun Jeon a, So-Hyoung Lee b, Boon Jo Rho c, Ki-Bong Oh b,⇑, Jongheon Shin a,⇑ a Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Republic of Korea b Department of Agricultural Biotechnology, College of Agriculture Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Republic of Korea c Department of Biological Science, College of Life Science, Ehwa Womans University, 52 Ehwayeodae-gil, Seodaemun, Seoul 120-750, Republic of Korea a r t i c l e i n f o a b s t r a c t Article history: Six b-carboline alkaloids (1–6) of the eudistomin Y class were isolated from the Korean ascidian Synoicum Received 23 March 2012 sp. These compounds were chemically converted to a known compound, eudistomin Y1 (7) and six new Revised 30 April 2012 derivatives, designated eudistomins Y8–Y13 (8–13). Several of these natural and synthetic compounds Accepted 2 May 2012 exhibited moderate to significant antimicrobial activity, weak cytotoxic activity, and inhibitory activities Available online 11 May 2012 + + toward sortase A, isocitrate lyase, and Na /K ATPase. Structure