农药致慢性细胞毒性和基因毒性机制研究进展.PDF

２０１７年　 第 １２卷 生 态 毒 理 学 报 Vol. 12, 2017 第 １期ꎬ８２￣８８ Asian Journal of Ecotoxicology No.1, 82￣88 DOI:10.7524/AJE.1673￣5897.20160405001 陈洁, 张积仁. 农药致慢性细胞毒性及基因毒性机制研究进展[J]. 生态毒理学报ꎬ2017, 12(1): 82￣88 Chen J, Zhang J R. Progress in mechanism of pesticide￣induced cytotoxicity and genotoxicity [J]. Asian Journal of Ecotoxicology, 2017, 12( 1): 82￣88 (in Chinese) 农药致慢性细胞毒性及基因毒性机制研究进展 1 2,* 陈洁 ꎬ 张积仁 1. 南方医科大学珠江医院肿瘤中心ꎬ广州510282 2. 广东省靶向肿瘤干预与防控研究院ꎬ清远511500 : : 收稿日期 2016￣04￣05 　 　 录用日期 2016￣07￣03 摘要:大量流行病学研究和体内、体外检测分析表明ꎬ长期低剂量接触农药可以导致人体细胞和分子损伤ꎬ诱导细胞凋亡ꎮ 农 药致细胞及DNA 损伤的机制主要与DNA 加合物的形成、DNA 单链和/或双链的断裂有关ꎮ 此外ꎬ氧化应激参与农药致细胞 及DNA 损伤的过程ꎬ可能成为农药致细胞及DNA 损伤的促发因素ꎮ 从总体上看ꎬ其具体分子机制还不十分清楚ꎬ有待进一 步研究ꎮ 关键词:农药ꎻ细胞毒性ꎻ基因毒性ꎻ氧化应激 文章编号:1673￣5897(2017)1￣082￣07　 　 中图分类号:X 171.5　 　 文献标识码:A Ｐｒｏｇｒｅｓｓ ｉｎ Ｍｅｃｈａｎｉｓｍ ｏｆ Ｐｅｓｔｉｃｉｄｅ￣ｉｎｄｕｃｅｄ Ｃｙｔｏｔｏｘｉｃｉｔｙ ａｎｄ Ｇｅｎｏｔｏｘｉｃｉｔｙ 1 2,* Chen Jie , Zhang Jiren 1. Zhuj iang Hospital of Southern Medical University, Guangzhou 510282, China 2. Guangdong Institute of Tumor Target Intervention and Prevention, Qingyuan 511500, China Ｒｅｃｅｉｖｅｄ 5 April 2016　 　 ａｃｃｅｐｔｅｄ 3 July 2016 Ａｂｓｔｒａｃｔ:The cytotoxicity and genotoxicity in human cells induced by chronic exposure of pesticides have been confirmed, proved by the epidemiologic studies and many alternative test methods in vivo and in vitro. The forma￣ tion of DNA adduct and DNA single and/or double strand breakage are the main forms of DNA damage. In addi￣ tion , oxidative stress plays an important role and may be a promoting factor in the mechanism of pesticide￣induced cytotoxicity and genotoxicity in human cells. Overall, the specific molecular mechanism of pesticide is not entirely clear at present and further researches are needed to be done. Ｋｅｙｗｏｒｄｓ:pesticide; c