阿托伐他汀调节PI3KAkteNOS途径对UUO小鼠管周微血管密度的影响及机制.pdfVIP

cells in the three groups all reached to peak in the first week and wre more higher than the normal control group, UUO group was much higher than Sham group, ATO group was much higher than UUO group, and there were statistical significance(P0.05). + + The percentage of CD133 /VEGFR2 cells in peripheral blood mononuclear cells in the three groups gradually deacreased after 1 week, in Sham group there was no statistical significance comparing to normal control group at 2 、3、4 week(P0.05), UUO group decreased under normal at 2 week and was much lower than normal control group at 3、4 week(P0.05), ATO group was much higher than normal control group during the whole experiment(P0.05). ③ The degree of tubulointerstitial injury(TI)evaluation: In Sham group the TI evaluation had no apparently changes during the whole experiment, In UUO and ATO groups TI gradually increased along with the surgrey,it was much higher than that in Sham group at the corresponding time period (P0.05),but ATO group was lower than UUO group at every time of point(P0.05). ④Akt and p-Akt expression: In Sham group the Akt and p-Akt in renal interstitium had no apparently changes during the whole experiment, in UUO group Akt and p-Akt were much more higher than that in Sham group,statistical significanc existed between the two groups at 1 week(P0.05), then Akt and p-Akt gradually decreased, comparing to Sham group it was significant lower at 3、4 week(P0.05), in ATO group Akt and p-Akt were reached to peak in the first week, and then gradually deceased along with surgrey, it was higher than Sham and UUO groups at the corresponding time period during the whole group(P0.05). ⑤ eNOS expr