阿托伐他汀钙对新西兰兔糖代谢的影响.pdfVIP

高剂量他汀组降低更明显。 （7 ） 胰岛素敏感性实验(IVITT)中：各实验组之间无差别 结论 1. 阿托伐他汀钙有显著的降脂作用， 2. 阿托伐他汀钙主要通过抑制胰岛素的分泌影响糖代谢。 关键词： 新西兰兔、阿托伐他汀钙、糖耐量实验、血糖、胰岛素 2 The Influence of Atorvastatin Calcium on the Glucose Metabolism of New Zealand Rabbits Abstract Research background As a kind of cholesterol-lowering drug, statin had received wide clinical application, especially in the Cardiovascular Department, for it could not only reduce the probability of myocardial infarction for patients with coronary heart disease, but also reduce the death rate of patients with myocardial infarction through anti-inflammatory and anti-apoptotic measures. Researches had shown that pre-accommodation of atorvastatin calcium can also protect the acute ischemic myocardium with [1] reperfusion through improving the expression of eNOS and (iNOS) mRNA . However, substantial clinical studies and meta-analysis [2.3] had shown that statin drugs would influence the glucose metabolism and increase the risks of diabetes. This project aims to discuss the influence of atorvastatin calcium on the glucose metabolism according to the experiments on New Zealand rabbits. Objective To discuss the influence of atorvastatin calcium on the glucose metabolism of New Zealand rabbits Method High-fat diet was adopted to feed the New Zealand rabbits for two months. After the high-fat animal model, the New Zealand rabbits were divided into pure high-fat group (which is fed with high-fat diet for another three months), low-dose statin group (1mg/kg atorvastatin calcium + high-fat diet for another three months), high-dose statin group (2.5mg/kg atorvastatin calcium + high-fat diet for another three months) and normal group (fed with ordinary diet for 5 months). The venous blood had been drawn