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基因组的不稳定性与肿瘤
2001 ; 5(4)
332 Chin J Dis Contr ol P r ev Dec
基因组的不稳定性与肿瘤
陈传德, 吴中亮, 雷毅雄
( microsatellite, MS) ( variable number of tandem
repeat,VNTR) , ,
,
, M S VNTR
; ; DNA, ;
73 31; 394. 3 1008 6013( 2001) 04 0332 03
R R A
Genomic instability and tumorCHEN Chuan de, WU Zhong liang, LEI Yi xiong. R es earch
I nst it ute For Chem ical Carc inog enesis, Guangz hou M ed ical Colleg e, Guangz hou 510182, Ch ina
.
Abstract T he explorat ion of tumor mechanism has become popular in recent years Genetic
researches indicate that genomic inst ability is much relat ed to the generation and development of
t umor. Microsatellite and VNT R are all highly repetitive sequences, having the polymorphism of
length, which causes the genomic instability . But now , there are few reports about the
relationship betw een genomic inst ability and tumor. Here we review t he relat ionship betw een
gemomic inst ability and tumor in tw o aspects of microsatellite and VNT R.
Key wordsgenome; neoplasms; DNA, satellit e; mutation
( Ch in J D is Contr ol P r ev 2001, 5( 4) : 332 334)
1. 1MS MS DNA
DNA , MS 16
, , , 23 4
, ( ) ( )
CA n TG n
, , 1060 MS
, (microsatellite, , 53
MS) (variable number of ,
tandem repeat, V NTR) 1. 2 (
MS
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