非痴呆型血管性认知障碍的静息态功能磁共振研究.pdfVIP

【结论】 1．VCIND 患者存在执行功能、注意力、语言等多项认知障碍。 2 ．VCIND 患者在静息状态下表现出异常的前扣带回神经网络改变，尤其默认网 络存在明显异常。 3 ．左顶下小叶、右额上回等脑区与ACC 的功能连接异常对VCIND 的认知具有 潜在的临床预测价值。 【关键词】 血管性认知障碍，前扣带回，静息态功能磁共振，功能连接 A study of resting-state functional magnetic resonance imaging in vascular cognitive impairment of no dementia Abstract 【Objective】 We investigated the abnormal neural network changes of anterior cingulated cortex （ACC ）in vascular cognitive impairment of no dementia （VCIND ）and analysed the changes with the MOCA scores by correlation analysis, to explore the brain areas which showed potential clinical prediction value for the cognitive function of VCIND. 【Methods 】 1.The MoCA scale was used to explore the cognitive function in 14 VCIND patients(inclusion criteria:right-handed,45 to 80 years old,above elementary school,subcortical ischemic cerebrovascular disease confirmed by MRI,the scores of MOCA(Beijing version)were under 26 points;exclusion criteria:systemic diseases which may cause cognitive impairment,Neurological diseases which may lead to cognitive impairment,depression and psychiatric patients,drug abuse or chemical poisoning which may disturb the study,physical function defects such as aphasia or audio-visual obstacles which may get in the way of evaluation),as well as 16 healthy elderly subjects(the control group). 2.ACC connectivity was acquired from all subjects by functional connectivity(FC) method. 3.The functional connection strength of anterior cingulated cortex was analysed with the MOCA scores by correlation analysis. 【Results 】 1.The visual space/executive function,language,attention/ computing power ，language directionnal power items,and the total points of MoCA with VCIND are sig