非肌层浸润性膀胱癌治疗现状及展望.pdfVIP

Non muscle invasive bladder cancer treatment status and Prospect [Abstract]Bladder tumor is our genitourinary system are the most common tumor in China, occupies the first, in foreign countries accounted for second.90% of them above the bladder tumor for urothelial carcinoma ( urothelial carcinoma, UC ), bladder cancer can be divided into non muscle invasive bladder cancer ( non-muscle invasive bladder carcinoma, NMIBC ) and muscle-invasive bladder cancer, in which the NMIBC accounts for the vast majority, about 75% ~ 85%. Muscle invasive bladder cancer accounts for 15% ~ 25%. In NMIBC, about 70% for stage Ta lesions,20% for stage T1lesions,10% for bladder carcinoma in situ. Treatment of NMIBC are mainly treated with operation, TUR-BT is the traditional operation mode, but the exact effect. Nearly twenty years the emerging holmium laser and PDT has simple operation, small wound, fast recovery and other advantages, and has proven to be effective treatment method. Post-operative adjuvant chemotherapy, can reduce the rate of tumor recurrence, but could not prevent tumor progression. Bladder perfusion according to the situation of patients can be a single or combined medication. Low risk of SBC after TUR, the preferred single chemical drug perfusion. In high risk SBC after TUR, BCG as the preferred drug perfusion in the treatment of. Along with the molecular biology of the cell and tumor immunology, on the pathogenesis of bladder cancer awareness change rapidly, new diagnosis, operation treatment and new drug perfusion such as bamboo shoots after a spring rain like appearance, treatment of bladder tumors will have greater development. [ Key words] bladder tumor; non muscle invasive bladder cancer; superficial bladder cancer; therapy; review 1 NMIBC 的治疗 1.1 手术治疗 1.1.1 经尿道膀胱肿瘤电切除术(TUR-BT) NMIBC 主要的治 疗手段是 TUR-BT。膀胱肿瘤的确切病理分级、分期都需要借 [1,2] 助首次TUR-BT