122例卵巢早衰患者中医证候分析及致病因素调查　论文.docVIP

　　122例卵巢早衰患者中医证候分析及致病因素调查　论文 .freele and its distribution regularity of premature ovarian failure (POF) as e of it. Methods The pathogeic condition and etiological factor of 122 patients e differentiation . Results The TCM symptoms of POF manifested the tendency of variety. Among the 122 cases, Gan-stagnation and Shen-deficiency type accounted for 33.61% of them, Gan-Shen yin deficiency type for 18.03%, Pi-Shen yang deficiency type for 15.57%, Jin damage due to excessive heat type for 15.57%, Shen-deficiency blood stasis type for 8.20%, and Gan-stagnation and Pi- deficiency type for 7.38%. The influence of modern living environment and life style to the disease otion, 31.97% by drugs and disease, and 4.92% by both of them. In patients induced by emotion, the proportion of Gan-stagnation and Shen-deficiency type age due to excessive heat type as ost, but no significant difference ong them (P 0.05). Conclusion Gan-stagnation and Shen-deficiency type, Gan-Shen yin deficiency, Pi-Shen yang deficiency type and Jin damage due to excessive heat are the monly encountered syndromes in patients odern living environment and life style have the promotion in the genesis of POF. Key ature ovarian failure；TCM syndrome；etiological factor 卵巢早衰(Premature Ovarian Failure,POF)是指女性40岁以前出现月经量少、后错,甚至闭经,同时伴有潮热、汗出、心慌、烦躁、失眠等围绝经期症状。流行病学调查数据表明,卵巢早衰在一般人群中患病率为1%～3%；在原发性闭经患者中患病率为10%～28%,在继发性闭经患者中患病率达4%～18%1。近年来卵巢早衰发病呈逐年上升趋势。本研究以122例卵巢早衰患者作为研究对象,通过病证结合,探讨卵巢早衰的中医症状、证候分布以及卵巢早衰中医证候与发病因素的相关性。 1 资料与方法 1.1 一般资料 选择2003－2006年间在首都医科大学附属北京中医医院妇科门诊就诊,诊断符合卵巢早衰的患者122例。年龄15～40岁,平均(32.04±5.39)岁；病程4～180个月,平均(39.00±40.21)月；血清促卵泡生成素(FSH)为(82.98±31.73)IU/L,雌二醇(E2)为(22.26±20.03)pq/mL。122例卵巢早衰患者中,发病后曾用激素治疗者75例(61.48%),未用激素治疗者47例(38.52%)；发病人群中有流产史者43例(35.25%),无流产史者79例(64.75%)。 1.2 诊断标准 女性40岁以前有至少4个月以上停经史,并有2次或以上血清FSH 40 IU/L(2次检查间隔1个月以上),E2 25 pq/mL,即可诊断卵巢早衰1-2。根据国家技术监督局发布的国家标准《中医临床诊疗术语·证候部分》对有关证候的定义进行中医辨证。 1.3 研究方法 对122例卵巢早衰患者进行病情及病因调查。病情调查内容包括：患者病程、体征、中医症状、血清女性激素测定等；病因调查内容包括：患者月经史(初潮年龄、闭经前月经情况、闭经期限)、孕产史(