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雌激与素受体、孕激素受体在子宫内膜息肉中的表达及宫腔镜诊治的价值
12010-5-9 修稿
雌、孕激素受体在子宫内膜息肉中的表达及宫腔镜对子宫内膜息肉的诊治价值
郑瑞芹 刘晓芹 张建英
【摘要】目的:探讨雌激素受体(ER)、孕激素受体(PR)与子宫内膜息肉(EP)的关系,以及宫腔镜对子宫内膜息肉的诊治价值。方法:因不孕行宫腔镜检查发现子宫内膜息肉的60例患者,宫腔镜下进行诊治,镜下用抓钳完全抓取息肉后行刮宫术,应用免疫组化检测息肉组织及正常内膜组织中ER、PR的表达。结果: ER在子宫内膜息肉组与正常子宫内膜组中的表达无明显差异(Z=0.276,P=0.782); PR在子宫内膜息肉组中的表达明显低于其在正常子宫内膜组中的表达,差异有统计学意义(Z=2.390,P=0.017)。结论:(1) PR在EP中的低表达可能与EP 的形成有关;(2)宫腔镜是EP诊断和治疗的首选方法;(3)子宫内膜息肉是不孕的重要原因之一。
【关键词】子宫内膜息肉;雌激素受体;孕激素受体;宫腔镜
The Expression of Estrogen Receptor,Progesterone Receptor in Endometrial Polyps and the Value of Diagnosis and Treatment by Hysteroscopy
ZHENG Rui-qin, LIU Xiao-qin, ZHANG Jian-ying
(Department of Infertility and Sterility, Huantai Maternal and Child Health Hospital, 256400)
【ABSTRACT】Objective To investigate the relationship of estrogen receptor (ER)、progesterone receptor (PR) and endometrial polyps(EP) and to study the value of diagnosis and treatment to endometrial polyps by hysteroscopy.Methods A total of 60 infertile patients presenting with endometrial polyps which were found in hysteroscopy were included in the study. Endometrial polyps collected by grasping forceps under hysteroscopy were used as experimental group. On the other hand, endometriums collected by dilation and curettage performed after total removal of endometrial polyps were used as control group. The expressions of ER、PR in EP and normal endometrium were assayed by immunohistochemical method. Results The expressions of ER in EP haven’t evident difference than in control group(Z=0.276,P=0.782) , the expressions of PR in EP were significantly lower than that in control group. The difference was statistically significant(Z=2.396,P=0.017). Conclusion (1) Lower expressions of PR in EP were probably associated with EP formation. (2)Hysteroscopy is the preferred method of treatment of EP. (3) EP is one of significant causes of infertility.
【Key words】Endometrial Polyps; Estrogen Receptor; Progesterone Receptor; Hysteroscopy
子宫内膜息肉(endometrial polyps,EP) 是子宫内膜腺体和间质以及伴随的血管过度生长,有蒂向宫腔内突出,形态多
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