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癌症生物学课件3(国外)
Angiogenesis
BIO387 – Cancer Biology
Dr Debbie Cunningham
d.cunningham@bham.ac.uk
Judah is going to cure cancer
in two years
Dr. James Watson
Judah is going to cure cancer
in two years
Dr. Judah Folkman
What is Angiogenesis?
• The growth of new blood vessels from
existing vasculature
endothelial
cell
vessel lumen
/2006/051906/images/angiogenesis_web.jpg
What is Angiogenesis?
• The growth of new blood vessels from
existing vasculature
sprouting
angiogenesis
/2006/051906/images/angiogenesis_web.jpg
Angiogenesis
• Not to be confused with vasculogenesis,
which is the formation of blood vessels
from progenitors during development
Cardiovascular physiology
• Why do we need blood?
– Delivery of oxygen and nutrients
– Removal of CO2 and waste products
– Acid/base balance
capillaries
de-oxygenated
venous blood
oxygenated
arterial blood
tissue
Nature Medicine 9, 713 - 725 (2003)
Angiogenesis
• Situations where angiogenesis occurs:
– Development
– Wound healing
– Bone fractures
– Menstrual cycle
– Pregnancy
Angiogenesis
• Stimulated by:
– Increased tissue mass
– Reduced oxygen levels (hypoxia)
– Inflammation
Angiogenesis
1. Angiogenic factors bind to receptors 1
on the surface of endothelial cells
2. Endothelial cells at sp
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