内布拉斯加大学医学中心（实验室轮转）交流心得.pdf-.PDF

University of Nebraska Medical Center 姓名：刘丹 学号：083328 参加项目名称： 美国内布拉斯加大学医学中心实验室项目 时间：2012 年 4 月 -2012 年 7 月 During last two months, I’ve spent a wonderful time with TCF/LEF family transcription factors to promote in UNMC. I’ve done some scientific researches in the specific gene expression. laboratory and improved myself in scientific thinking β-cat is pivotal molecule. When teamed up with TCF and new techniques. I’ve also felt the differences factors, β-cat activates Wnt target gene expressionβ- between Chinese and American culture through catenin/TCF is a bipartite transcription factor, and is talking with American people, working with them, regarded as the major effector of the canonical Wnt having dinner with them and traveling with them. signaling pathway Now I would like to share my experience about the KIAA1199 is a protein without a defined function in scientific research and interesting life in UNMC. breast cancer , is highly expressed in three basal type B breast cancer cell lines and the expression of I’ve participated in two subjects of research and this gene is significantly correlated with the invasive have received some results. ductal carcinoma type of breast cancer . Repression of KIAA1199 attenuates Wnt-signaling. Subject 1 “The Interaction between KIAA1199 is also found to be similar to the APC. KIAA1199 and β-catenin”. As is i