Alternative isoform regulation in human tissue transcriptomes-英文文献.pdf

NIH Public Access Author Manuscript Nature . Author manuscript; available in PMC 2009 May 27. N Published in final edited form as: I H Nature . 2008 November 27; 456(7221): 470–476. doi:10.1038/nature07509. - P A A u Alternative Isoform Regulation in Human Tissue Transcriptomes t h o r 1,2,* 1,3,* 4 4 4 Eric T. Wang , Rickard Sandberg , Shujun Luo , Irina Khrebtukova , Lu Zhang , M 5 6 4 1,7 a Christine Mayr , Stephen F. Kingsmore , Gary P. Schroth , and Christopher B. Burge n 1 u Dept. of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA s c 2 r Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139 USA i p t 3Dept. of Cell and Molecular Biology, Karolinska Institutet, 171 77 Stockholm, Sweden 4 Illumina Inc., 25861 Industrial Boulevard, Hayward, CA 94545 USA 5Whitehead Institute for Biomedical Research, Cambridge, MA 02142 USA 6National Center for Genome Resources, 2935 Rodeo Park Drive East, Santa Fe, NM 87505 USA N I H - Abstract P A Through alternative processing of pre-mRNAs, individual mammalian genes often produce A multiple mRNA and protein isoforms that may have related, distinct or even opposing functions. u t h Here we report an in-depth analysis of 15 diverse human tissue and cell line transcriptomes based o on deep sequencing of cDNA fragments, yieldi