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哌拉西林钠他唑巴坦钠 ACC产品-哌拉西林他唑巴坦和实验之间的相互作用
Infection(2010)38:217–221DOI10.1007/s15010-010-0003-6
BRIEFREPORT
Theinteractionbetweenpiperacillin/tazobactamandassaysforAspergillusgalactomannanand1,3-beta-D-glucaninpatientswithoutriskfactorsforinvasivefungalinfections
?kusG.Metan?C?.Ag??H.Buldu?A.N.Koc?
Received:27August2009/Accepted:12January2010/Publishedonline:17March2010
óUrbanVogel2010
Abstract
BackgroundTheaimofthisstudywastoinvestigatetheinteractionbetweenintravenouspiperacillin/tazobactamtreatmentandAspergillusgalactomannanantigen(GM)and1,3-beta-D-glucan(BDG)testresultsinpatientswith-outknownriskfactorsforinvasivefungalinfections(IFI).PatientsandmethodsPatientswithoutknownriskfactorsforIFIandwhoweretoreceivepiperacillin/tazobactammonotherapywereconsideredeligibleforthestudy.Serumsampleswereobtainedbothbeforeandafterantibioticinfusiononthe?rst,third,seventhandtenthdaysofapiperacillin/tazobactamtreatmentcourseand4daysafterthelastdose.GMwasdeterminedbyPlateliaAspergillusELISA(Bio-RadLaboratories)andBDGwasassayedusingtheFungitellkit(AssociatesofCapeCod,EastFal-mouth,MA)accordingtomanufacturers’speci?cations.ResultsAtotalof135serumsampleswerecollectedfrom15patients.Whenacut-offlevelofC0.7wasusedforGMpositivity,therewerenofalsepositiveresults.Whenacut-offlevelofC0.5wasused,sixserumsampleswerepositive.
Therewerenostatisticallysigni?cantdifferencesbetweenthemedianGMindicesormedianBDGlevelsofthevari-oussamplingtimes.However,24of135serumsampleswerepositiveforBDGforathresholdof80pg/mL.AfterrulingoutfungalinfectionsandallknownpotentialcausesoffalseBDGpositivity,environmentalcontaminationremainedapossiblecauseofBDGreactivity.
ConclusionNosigni?cantinteractionwasobservedbet-weenpiperacillin/tazobactamadministrationandAsper-gillusGMandBDGassays.PositiveresultsforthesetestsshouldbeevaluatedcautiouslyinpatientsathighriskforIFIreceivingpiperacillin/tazobactam.
KeywordsAspergillusgalactomannanantigená1,3-Beta-D-glucanáFalsepositivityáPiperacillin/tazobactam
Introduction
Invasivefun
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