Chapter21病毒的感染与致病机制—培训课件.ppt

inherent barriers Skin, Mucus, Ciliated epithelium?, Low pH? NK cell humoral and cellular components interferon (IFN) complement cytokines: TNF-α, IL-1 and IL-6… Non-specific immunity Interferon（ IFN） concept: A class of protein (glycoprotein ) produced by cells in response to viral infection or other interferon inducers that protected other cells of same species from attack by a wide range of viruses. production of IFN: interferon inducers: PolyI:C virus bacterial endotoxin, etc production of IFN: IFN inducer acts on cell receptors IFN gene activation IFN mRNA transcribe IFN synthesis IFN released Characteristics : 1）not act directly on virus 2) broad-spectrum antiviral activity 3) host species specific: inhibit viral replication only in the species in which it was produced 4)Immuno opsonization and anti-tumor classification of IFNs: Hu IFN; Mu IFN…… IFN-α IFN-β IFN-γ Gene chromosome 9 chromosome 9 chromosome 12 cell blood mononuclear cell fibroblasts Ag-activated T cell anti-viral +++ +++ ++ Activity Modify- immune ++ ++ +++ responses antiviral activity: cannot act directly on virus, but through induction of antiviral proteins (AVP). IFN 抗病毒作用示意图 Mechanisms: IFN combines cell surface AVP gene activation