2型糖尿病下肢血管病变与kruppel样因子4,可溶性p选择素,超敏C反应蛋白关系的研究.pdfVIP

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2型糖尿病下肢血管病变与kruppel样因子4,可溶性p选择素,超敏C反应蛋白关系的研究.pdf

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2型糖尿病下肢血管病变与kruppel样因子4,可溶性p选择素,超敏C反应蛋白关系的研究论文

control group ，and the differences in body mass index(BMI) ，blood pressure(BP) ，serum glucofe，HbA lc, and Bloodlipid were also observed . Result: Compared with the N-PVD group and the control group, the level of hsCRP and Ps were both significantly incressed(the hsCRP level: PAD vs N-PVD 77.44±8.59 vs 61.16±9.41 ，P=0.003; PAD vs control 77.44±8.59 vs 44.48±6.15 ，P ＜0.001. the Ps level ：PAD vs N-PVD 142.42±13.46 vs 117.87±14.27，P=0.002; PAD vs control 142.42±13.46 vs 90.91±8.09 ，P ＜0.001); however, the KLF4 level in PVD group was significantly lower than that of N-PVD group and control group( PAD vs N-PVD 34.72±5.41vs 44.88±7.05 ，P=0.019 ；PAD vs control 34.72±5.41 vs 53.74±7.38 ，P ＜0.001).In addition, we found that N-PVD group had higher level in hsCRP and Ps than control group(the hsCRP level: N-PVD vs control 61.16±9.41 vs 44.48±6.15 ，P=0.002 ；the Ps level: N-PVD vs control 117.87±14.27 vs 90.91±8.09, P=0.001), yet the KLF4 level was decreased markedly in N-PVD group compared with the control group(N-PVD vs control 44.88±7.05 vs 53.74±7.38, P=0.04). Conclusion: hsCRP, Ps as well as KLF4 have the similar clinical importance for the onset and progress of Type 2 diabetes complicated with PVD ．High hsCRP and Ps levels may be the pivotal risk factors of PVD in TzDM patients, and furthermore, the study suggest that KLF4 is likely to alleviate peripheral vascular disease in Type 2 diabetes patients. But further research still be indispensably in order to explicit the effects and concrete mechanism of these factors on peripheral vascular disease in Type 2 diabetes patients . Key words: peripheral vascular disease; Type 2 diabetes; high-sensitivity C-reactive Protein; soluble P-selection; Kruppel-like factor 4