3-位取代靛红衍生物的成环反应的合成与方法学分析.pdfVIP

Abstract Thisthesis is conceredwith 3-substutide isdine isdine andits derivatives cyclization reaction with conjugated diene and salicylic aldehyde. It mainly consists of the followingthreeparts: PartoneIntroducesthesynthesisofisatinanditsderivativesandtheirparticipationin thecatalyticasymmetricsynthesisandtandomreactionbothathomeandabroad,give anoutlineofmeaning,methodandinnovationpointtothisresearch. Part two C-3position of isatin derivativewith dienevia [4+3]cycloaddition. In this part，wefirstreportedthesynthesisofheterocyclicderivateonC-3positionofisatin, totrymanydifferentkindsofconditionanddienes,wefoundthatMg(ClO) inDCM 4 2 is the most efficient way to form the seven number skeleton. Using H-NMR1 13C-NMRandX-raycrystalstructureanalysistoconformthestructureoftheproduct. PartthreeThetandemreactionofIsatinderivativeswithsalicylaldehyde.Inthispart, we give a short introduce about salicyl aldehyde and salicylic imines with α,β-unsaturated compounds. Our team first use C-3 position unsaturated isatin derivativeswith salicylaldehydevia atandemMichael-Aldolreaction successfuland effective build a spiro-[5,6] benzopyrrole skeleton. The product was verified by 1 13 H-NMR C-NMRandX-raycrystalstructureanalysis. Keyword:3-subsitutedisatin [4+3]cycloaddition salicylaldehyde tandemMichael-Aldolreaction III 目 录 第1章 靛红及其衍生物在合成中的研究综述1 1.1 选题的依据和意义1 1.2 含有吲哚骨架的天然产物综述1 1.3含有靛红骨架的天然产物的综述3 1.3.1孕酮受体调节类激素3 1.3.2 含靛红骨架的抗肿瘤类天然产物4 1.3.3含靛红骨架的抗HIV活性的结构5 1.4 靛红的概论与合成方法5 1.4.1 贝耶尔合成法5 1.4.2 克莱森合成法6 1.4.3 桑德迈尔合成法6 1.4.4 过渡金属催化氧化合成法6 1.5 靛红及其衍生物参与的串联反应研究进展7 1.5.1 串联反应合成吲哚螺吡喃环衍生物7 1.5.2