慢性压迫性脊髓症基质金属蛋白酶9表达与血脊髓屏障破.PDF

路456路 涓崕楠ㄧ鏉傚織2015骞?鏈堢35鍗风4鏈 ChinJOrthop,April2015,Vol.35,No.4 路鍩虹涓庨鐥吢 鎱㈡€у帇杩€ц剨楂撶棁鍩鸿川閲戝睘铔嬬櫧閰垛亙9琛ㄨ揪 涓庤鑴婇珦灞忛殰鐮村潖鐨勭浉鍏虫€х爺绌 榫欏帤娓 闄堟枃绔 璋㈡枃鏋 鏉庡箍鐩 寰愭櫠杈 绋嬫槦 鑳″媷 鏉庝經淇 銆愭憳瑕併€ 鐩殑 瑙傚療鎱㈡€у帇杩€ц剨楂撶棁澶ч紶妯″瀷鑴婇珦鍩鸿川閲戝睘铔嬬櫧閰垛亙9锛坢atrixmetalloproteinase鈦?,MMP鈦?锛夎〃杈惧拰 琛€鑴婇珦灞忛殰锛坆loodspinalcordbarrier,BSCB锛夌殑鍙樺寲锛屾帰璁ㄤ簩鑰呯浉鍏虫€с€傛柟娉 灏?8鍙垚骞碨D澶ч紶闅忔満鍒嗕负鍋囨墜鏈粍鍜 鑴婇珦鍘嬭揩缁勶紝姣忕粍鍚?4鍙紱灏嗗惛姘村悗鍙啫鑳€鑱氭皑閰杽鏉挎鍏5妞庢澘涓嬬‖鑶滃锛屽缓绔嬫參鎬у帇杩€ц剨楂撶棁妯″瀷銆傞€犳ā鍚庣4 鍛紝涓ょ粍鍒嗗埆閫氳繃BBB锛圔assoBeattieBresnahan锛夎瘎鍒嗗拰浣撴劅璇卞彂鐢典綅锛坰omatosensoryevokedpotential,SEP锛夋娴嬭瘎浠疯剨楂 鍔熻兘锛屾瘡缁勫悇鍙?2鍙MMP鈦?銆佸唴鐨睆闅滄姉鍘燂紙endothelialbarrierantigen,EBA锛夊厤鐤粍鍖栨煋鑹层€佹娴嬩簩鑰呭湪鑴婇珦涓嶅悓鍖哄煙琛 杈炬儏鍐碉紱鍏朵綑12鍙浼婃枃鎬濊摑锛坋vansblue,EB锛夌亴娉ㄦ娴婤SCB閫氶€忔€с€傜粺璁″鏂规硶姣旇緝涓ょ粍鍚勮瀵熸寚鏍囧樊寮傦紝骞跺垎鏋愯剨 楂撳帇杩粍MMP鈦?涓嶦BA琛ㄨ揪鍙樺寲鐨勭浉鍏虫€с€傜粨鏋 鎴愬姛閫犳ā鍚庣4鍛ㄨ剨楂撳帇杩粍BBB璇勫垎鏄捐憲浣庝簬鍋囨墜鏈粍锛涚浉瀵逛簬 鍋囨墜鏈粍锛岃剨楂撳帇杩粍SEP妫€娴嬫綔浼忔湡鏄捐憲寤堕暱銆佹尝骞呮樉钁楅檷浣庛€傝剨楂撳帇杩粍鐧姐€佺伆璐∕MP鈦?琛ㄨ揪鍧囨樉钁楅珮浜庡亣鎵嬫湳缁勶紝 鑴婇珦鍘嬭揩缁勭伆璐‥BA琛ㄨ揪鏄捐憲浣庝簬鍋囨墜鏈粍锛岀櫧璐‥BA琛ㄨ揪鏃犳樉钁楀彉鍖栵紝鑴婇珦鍘嬭揩缁凟B鍚噺鏄捐憲楂樹簬鍋囨墜鏈粍锛涜剨楂撳帇 杩粍MMP鈦?琛ㄨ揪涓嶦BA琛ㄨ揪鍗婂畾閲忕粨鏋滆繘琛岄厤瀵规牱鏈浉鍏虫€у垎鏋愭樉绀轰袱鑰呭憟鏄捐憲鐩稿叧锛坮=0.96锛孭=0.000锛夈€傜粨璁 鎱㈡€ 鍘嬭揩鎬ц剨楂撶棁澶ч紶妯″瀷寤虹珛绗?鍛紝鑴婇珦鍔熻兘鏄捐憲闄嶄綆锛屽悓鏃禕SCB缁撴瀯鐮村潖銆侀€氶€忔€у鍔狅紝MMP鈦?琛ㄨ揪澧炲己骞朵笌EBA鎶楀師 鏄捐憲鍑忓皯鏄捐憲鐩稿叧锛屾彁绀築SCB鐮村潖鍙兘涓嶮MP鈦?琛ㄨ揪鏄捐憲澧為珮鐩稿叧銆 銆愬叧閿瘝銆 鑴婇珦鍘嬭揩鐥囷紱澶ч紶锛涘熀璐ㄩ噾灞炶泲鐧介叾9 ThecorrelationshipbetweenMMP鈦? expressionandtheblood饊喖spinalcordbarrierdisruptioninchroniccompressive cervicalmyelopathy LongHouqing*,ChenWenli,XieWenlin,LiGuangsheng,XuJinghui,ChengXing,HuYong,LiFobao. De鈦? partmentofSpineSurgery,theFirstAffiliatedHospitalofSunYat鈦僑enUniversity,Guangzhou 510700,China 銆怉bstract銆 Objective ToinvestigatethecorrelationbetweentheexpressionofMMP鈦? andthedisruptionoftheblood spinalcordbarrier(BSCB)inchroniccervicalcordcompressivemyelopathyratmodel.Methods 48adultratswererandomlydi鈦 videdintogroupA(shamsurgicalgroup, n=24)andgroupB(spinalcordcompressivegroup, n=24).Awater鈦僡bsorbingpolymer sheetwasimpla