医用有机化学_脂类.ppt

* * * * * * 2009年1月27日，全球最大药品制造商辉瑞制药与竞争对手惠氏宣布了并购计划 * * * * * * * * * * * * * * * * * * * * * * 1931年Butenandt从15吨男子尿中分离出15mg雄甾酮结晶；1935年又从雄仔牛睾丸中抽取到睾丸酮。 * 猪烯酮，雄甾烯酮，是猪的性费洛蒙，也是公猪身上的骚味来源 。雄烯酮是类固醇，大量存在于未阉割的公猪口水中，人类的男性与女性的汗水与尿液，以及芹菜的细胞质中也有极少量发现。雄烯酮是哺乳类动物中第一个被定义的费洛蒙。 * * * * * * * * Ru 486于1980年合成，1988年在法国获批准上市。1988年10月26日曾宣布停止供应，两天后法国政府命令必需恢复供应 /pubs_research/publications/downloads/professional_education/medical_abortion/faq_about_mifepristone.pdf * * * * * * * * * * * * * * BHA影响维生素D 的摄取。BHA对血清脂肪和胆固醇水平也有负面影响。日本、美国、部分欧洲国家禁用BHA . BHT常与BHA合用，抗氧化性强于BHA，但毒性大于BHA。TBHQ可用于食用油脂、油炸食品,亦可用于化妆品中. * * * 用0.5％柠檬酸加0.03％维生素C溶液或1％柠檬酸溶液处理，可保持48小时果皮不变色 * * * * * * * * * * * * * * * 人的红细胞膜中的脂质中含20％～30％鞘磷脂 * * * * * 选择性COX2抑制剂：主要抑制COX2的制剂，如美洛昔康、尼美舒利。 尼美舒利主要的用途是止痛和抗炎，不作为退烧的首选药物，但也不是禁忌 * * * * * * * * * * * * * * * * * * * Thus when soap dissolves in water, the nonpolar “tails” avoid water contact by formation of a “fluid” structure called a micelle. Only the - carboxyl groups are exposed to solvent (H2O). * Thus when soap dissolves in water, the nonpolar “tails” avoid water contact by formation of a “fluid” structure called a micelle. Only the - carboxyl groups are exposed to solvent (H2O). * Thus when soap dissolves in water, the nonpolar “tails” avoid water contact by formation of a “fluid” structure called a micelle. Only the - carboxyl groups are exposed to solvent (H2O). * * * * * * * * Redistribution of Fat in Glucocorticoid Excess Central obesity seen in Cushing’s Syndrome（库欣综合征） (Glucocorticoid Excess) * Buffalo hump * moon face * 3. Cholesterol (Cholesterin) Cholesterol was found in 1770. It has 8 chiral carbon atoms. The content in human body is 250g/75kg man. The presence of the hydroxyl group makes cholesterol amphipathic. * * * * * * * * * * Cholesterol decreases membrane fluidity and broadens the temperature range of melting of membranes by interfering with the orderly packing of lipid fatty acid side chains. * Cholesterol Reduces permeability Decreases fluidity , but increases