杏丁联合吡柔比星对膀胱癌T24细胞裸鼠移植瘤的化疗作用及机制分析.pdfVIP

calculated，at the same time also the interaction of the two drugs calculated by jin s formula ：xingding and THP. Light microscopy was used to observe the morphological changes. RT-PCR was used to detect Survivin 、caspase-3 mRNA expression. Results: The average volume of tumor were 682.0±36.6 mm3 in 3 xingding of low dosage group, 562.4±32.3 mm in xingding of medium dosage group, 496.0±15.6 mm3 in xingding of high dosage group, 505.0±35.9mm3 in THP low dosage group, 389.3±26.5 mm3 in THP routine dosage group, 3 3 375.3±23.5 mm in A group, 302.5±15.0 mm in B group. They were all lower than the control group ’s average volume857.6±71.8mm3 (P0.05). The average weight of tumor were 1.08±0.25g in xingding of low dosage group, 0.94±0.17g in xingding of medium dosage group, 0.86±0.16g in xingding of high dosage group,0.78±0.15g in THP of low dosage group, 0.61±0.13g in THP of routine dosage group,0.37±0.07g in A group ,0.50±0.09g in B group. They were all lower than the control group’s average weight1.26±0.20g (P0.05). according to the inhibition ratios of the tumor weight ,A group’s drug interaction( q) was 1.04, B group’s drug interaction( q) was 1.11. showed that the two kinds of medicine have additive action. Local necroses were observed in the tumor specimens by HE staining in xingding group, THP group and Xingding combined THP group. The Survivin mRNA expressed down- regulatedly when treated by Xingding of high-dosage combined with THP of low-dosage and THP of routine-dosage respectively (P0.05), the effect is better than THP. the Caspas-3 mRNA expressed up- regulatedly