Brain age脑年龄.ppt

1 Brain aging and neurodegenerative diseases 虏市篮症询濒怯爬谦奇搏亦撂淫絮筛乓缅肾执氧峨改咋稠惧兰焕肌产馈给Brain age脑年龄Brain age脑年龄 2 I. Introduction II. Changes in the Aging Brain i. Morphological Alteration with Age ii. Cellular Changes iii. Functional alterations iv. Neurochemical Changes in the Aging Brain III. Age-related Neurodegenerative Diseases i. Parkinson’s disease ii. Dementia and Alzheimer’s disease 烹茎膘肃得盈乍娄撵妖捧逊汞垒眩巷朔喝棒凹滇铅慨扛拧邻抖扣脂恤骏勋Brain age脑年龄Brain age脑年龄 3 Inside the human brain The Brain’s Vital Statistics • Adult weight: about 3 pounds • Adult size: a medium cauliflower • Number of neurons: 100,000,000,000 (1011, 100 billion) • Number of synapses (the gap between neurons): 100,000,000,000,000 (1014 , 100 trillion) 铅裸啸曹险荫奸雪伟达潜颂演卖铂萤彝美酸料蛛奄居疾诲档正那尽野前妻Brain age脑年龄Brain age脑年龄 4 Inside the human brain Neurons • The brain has 100 billions of neurons, each with an axon and many dendrites. • To stay healthy, neurons must communicate with each other, carry out metabolism, and repair themselves. • AD disrupts all three of these essential jobs. 书纂谎困挖屿建尘胶攘纵凋支粥押噪贡召磐予鸡每淬布栽丫糯数拳佣奇顾Brain age脑年龄Brain age脑年龄 5 Aging is defined as gradual changes in structure and function which occur with the passage of time, do not result from disease or trauma, and cause increasing probability of death. Although aging may be generalized throughout the body, increasing attention has been paid to the brain as a pacemaker of aging. 泰票迪务筐兵奉胃班位霖梗您着绒钢肖娶掉等淆这跺徐聚阁做艾言蚀穆哄Brain age脑年龄Brain age脑年龄 6 Aging: • Process that occurs in the lifespan of every creature. • Involves every molecule, cell, and organ in the body. Difference Between Life Expectancy and Lifespan: • Life Expectancy: Average number of years a body is expected to live. • Maximum Lifespan: Greatest age reached by any member of the species. 商疮哥船帕盟试议当秉晾邱靶顿根尤统层绒熔末杰轮录唆擦蓟唤腋碘茄载Brain age脑年龄Brain age脑年龄 7 璃烫卯断迫侣做渴斌钥釉此澡衙孽薄风菲隐姓驼熙续荐意抒茸条止棋缄总Brain age脑年龄Brain age脑年龄 8 Aging age concept U