年产500吨环丙沙星的生产工艺设计.docx

本 科 毕 业 设 计 (论 文)年产500吨环丙沙星的生产工艺设计Thedesign?process of?an annual output of 500 tons of?ciprofloxacin学 院： 化学工程学院 专业班级：****学生姓名：*****学 号：****指导教师：******2015 年 6 月毕业设计（论文）中文摘要年产500吨环丙沙星的生产工艺设计摘 要：环丙沙星,一种合成药物，为诺氟沙星分子中1位乙基被环丙基取代所得的喹诺酮类抗菌药。环丙沙星的合成是以3－氯－4－氟苯胺为起始原料，后与NaNO2发生重氮化反应，以及氯代后得到2，4－二氯氟苯，然后再通过与乙酰氯发生酰化反应，经过与碳酸二乙酯缩合，制得2，4－二氯－5－氟苯甲酰乙酸乙酯，产物再经过甲酰化、胺化，缩合成环得到1－环丙基－7－氯－6－氟－1，4－二氢－4－氧代喹啉－3－羧酸，最后在DMF溶液中与哌嗪反应，经过胺化制得环丙沙星，产物的总收率为17.8％。本设计由物料衡算、热量衡算、动量衡算，从而确定了设备，反应器、分离设备的选型，根据处理物料的条件确定了设备内壁的材料。本设计改进并优化了工艺流程和相关参数，使工艺流程得到了缩减，生产成本也得到了降低，具有良好的工业应用前景和开发价值。关键词：环丙沙星；喹诺酮类；合成药物；工艺设计 毕业设计（论文）外文摘要The design?process of?an annual output of 500 tons of?ciprofloxacinAbstract: Ciprofloxacin, a synthetic drug, for norfloxacin in a ethyl is cyclopropyl substituted income of quinolone antibacterial drugs.?Synthesis of ciprofloxacin in 3 - chloro - 4 - Fluoro aniline as the starting material, and NaNO2 diazotization reaction, and chlorinated obtained after 2, 4 - dichloro fluorobenzene, then with acetyl chloride acylation reaction, after carbonate and diethyl ester condensation of 2, 4 - chloro - 5 - pentafluorobenzoyl acid ethyl ester, the product through the formyl, amination, condensation rings 1 cyclopropyl - 7 - chlorine - 6 - Fluoro - 1, 4 - hydrogen - 4 - oxo quinoline - 3 -, carboxylic acid, and finally in DMF solution with piperazine reaction, after amination of ciprofloxacin, the product of the total yield was 17.8%.The design consists of material balance, heat balance, momentum balance, so as to determine the equipment, reactor, separation equipment selection, according to the material conditions to determine the material of the equipment wall..?The design improved and optimized the process flow and related parameters, so that the process has been reduced, the productionn cost has been reduced, and has good prospects for industrial application and development value..Keywords:Ciprofloxacin; quinolones; drug synthesis; process design目 录1 引言 …………