参松养心胶囊水提液陶瓷膜除杂工艺研究.PDFVIP

中草药 Chinese Traditional and Herbal Drugs 第 43 卷 第 1 期 2012 年 1 月 ·83 · 参松养心胶囊水提液陶瓷膜除杂工艺研究 王曙宾，郭珊珊，黄开毅 以岭药业北京以岭研究院，北京 102600 摘 要：目的 考察不同规格陶瓷膜对中药大品种参松养心胶囊水提液除杂的效果，并优化工艺参数。方法 以参松养心胶 囊水提液为研究对象，比较 3 种不同孔径的陶瓷膜在不同条件下，对膜通量衰减、药液有效成分保留率等方面的影响。结果 滤过孔径为 100 nm 的陶瓷膜对参松养心胶囊水提液滤过效果较好，膜通量及芍药苷转移率均较高，最佳滤过条件为进液压 力 0.15～0.22 MPa，滤过温度20 ℃。结论 陶瓷膜滤过技术可较好地对参松养心胶囊水提液进行除杂，该技术可进一步推 广到其他中药水提液的除杂工艺中。 关键词：参松养心胶囊；陶瓷膜；除杂技术；膜通量；芍药苷 中图分类号：R284.2 文献标志码：A 文章编号：0253 - 2670(2012)01 - 0083 - 03 Application of ceramic filter membrane in purification technology of water extract from Shensong Yangxin Capsule WANG Shu-bin, GUO Shan-shan, HUANG Kai-yi Beijing Yi-Ling Institute of Pharmaceutical Sciences, Yi-Ling Pharmaceutical Group, Beijing 102600, China Abstract: Objective To observe the effect of different pore diameter membranes on technologies of water extract from Shensong Yangxin Capsule and optimize the parameters. Methods Three different membranes were tested to observe the changes in membrane flux and the retention of effective components. Results The membrane with 100 nm diameter had the greater membrane flux, the transfer rates of paeoniflorin was the highest. The optimum conditions were that the operation differential pressure was 0.15—0.22 MPa, the operation temperature was 20 ℃. Conclusion A good result can be obtained by adopting the technology of ceramic membranes filtration to purify Shensong Yangxin Capsule, which provides the foundation for the application of ceramic membranes micro-filtration in the purification of water extract of other Chinese materia medica. Key words: Shensong Yangxin Capsule; ceramic membrane; purification technology; membrane flux; paeoniflorin 参松养心胶囊是以中医络病理论为指导，根据 优点，在中药提取分离中应用日益增多[3-5] 。有关陶 多年的临床经验研制而成的创新性抗心律失常中 瓷膜滤过后，对有效成分的影响方面，有报道其滤 药，可治疗快速性心律失常，同时该