丁香罗勒油透皮凝胶的制备及其体外透皮性能 - 中国实验方剂学杂志.doc

丁香罗勒油透皮凝胶的制备及其体外透皮性能 丁乐[1] 董健[2] 杨人泽[2]* （1赣州市妇幼保健院江西赣州 341000 2 赣南医学院第一附属医院 江西赣州 341000 ） 摘要：目的 制备一种丁香罗勒油透皮凝胶，观察其体外透皮性能。方法 以具有良好生物相容性的亲水性高分子材料羧甲基纤维素钠和聚乙烯醇为辅料，制备丁香罗勒油透皮剂。采用改良Franz扩散池，以鼠背皮肤为屏障进行经皮渗透实验，气相色谱法检测丁香罗勒油（以丁香酚为指标）的经皮渗透量。结果 羧甲基纤维素钠和聚乙烯醇两种高分子骨架材料在凝胶基质中的浓度对丁香罗勒油透皮能力有较大的影响，以25%含量（聚乙烯醇与羧甲基纤维素钠总量）为最佳。结论 丁香罗勒油透皮凝胶可用作为丁香罗勒油的良好载体有望极大地提高其功效。 关键词：丁香罗勒油；透皮凝胶；性能 Preparation of Ocimum gratissimum L. oil transdermal gel and its skin penetration in vitro DING Le[1], DENG Jian[2]， YANG Ren-ze[2] (1 Gan Zhou Maternal and Child Health Hospital, Gan Zhou Jiangxi 341000 2 The First Affiliated Hospital of Gan Nan Medical University Gan Zhou Jiangxi 341000) Abstract: Objective To prepare an Ocimum gratissimum L. oil transdermal gel and to investigate its skin penetration in vitro. Methods: An Ocimum gratissimum L. oil transdermal gel was prepared by using hydrophilic polymer sodium carboxymethyl cellulose and polyvinyl alcohol each with good biocompatibility. In the experimental installation for skin penetration in vitro, the mouse dorsal skin was isolated as a barrier for percutaneous penetration experiments. The percutaneous infiltration quantity of Ocimum gratissimum L. oil (eugenol as the indicator) was determined by high resolution gas chromatography. Results The ratio of polyvinyl alcohol and scarboxymethyl cellulose showed no significant effect on the transdermal ability of Ocimum gratissimum L. oil. But their concentration in the gel matrix had a certain influence on the transdermal ability of Ocimum gratissimum L. oil, and 25% content (total content of sodium carboxymethyl cellulose and polyvinyl alcohol) was optimal. Conclusion These results suggested that this kind of transdermal gel could be used as a good carrier for Ocimum gratissimum L. oil. Keywords: Ocimum gratissimum L. oil; Transdermal gel; Transdermal ability 丁香罗勒油为唇形科植物丁香罗勒 Ocimum gratissimum L. 的全草经水蒸气蒸馏得到的淡黄色挥发油，有类似丁香的香气，味辛辣[1]，是香料和日用化妆品工业的重要原料。丁香罗勒油的主要成分是丁香酚，其次含有芳樟醇，罗勒烯等。丁香罗勒油能抑制细菌生长，促进破损皮肤自然愈合，