中国医科大学病理学英文课件7.pptVIP

2. Mediators from plasma Complement S + kinin S + Clotting S 2) Complement System: (1) Consists of 20 component protein together with their cleavage products: present as inactive forms( C1~C9) (2) Functions : Increase vasopermeability (C3a, C5a) Cause vasodilation (C3a, C5a) Chemotaxist (C5a) Opsonization (C3b) C3a, 5a increase vascular permeability cause vasodilation by releasing histamine from mast cells C5a A powerful chemotactic agent for neutrophils basophils, eosinophils, monocytes Activates the lipoxygenase pathway of AA metabolism in monocytes, neutrophils → release of mediators 3) Clotting and fibrinolytic system ① Activated clotting system: i) Thrombin and fibrinopeptide: Thrombin promotes leukocyte adhesion fibroblast proliferation Fibrinopeptide increased V permeability chemotactic activity for leukocytes ii) Factor Xa increased V permeability leukocyte exudation ② Activated fibrinolytic system C3 C3a increase v permeability vasodilation Fibrin to fibrin products: increase v permeability 3. Summary of inflammatory mediators Function Major mediators Vasodilation histamine, bradykinin, PGI2, PGE2, NO Permeability histamine, bradykinin, LTB4, C3a, C5a, PAF Chemotaxis LTB4, C5a, cytokins, cationic protein Fever IL-1, IL-2, TNFa, PGE2 Pain PGE2 , bradykinin Tissue damage oxyradical, Lysosomal enzymes , NO V. Types and morphology of  acute inflammation Alterative inflammation Degradation, necrosis Acute sever