中国医科大学病理学英文课件8.pptVIP

下载本文档

2
0
约5.41千字
约 29页
2017-06-28 发布于上海
举报
版权申诉

中国医科大学病理学英文课件8.ppt

1、本文档共29页，可阅读全部内容。
2、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

中国医科大学病理学英文课件8

Section 8. Etiology and pathogenesis of tumor 8.1 Molecular basis of oncogenesis 8.1.1 Oncogene 1. Protooncogene , oncogene and products (1) Protooncogene: cellular genes that promote normal cell growth and differentiation, exist in normal cells, in the form of inactivity. (2) Oncogene: derived from protooncogene promote abnormal growth . (3) Mode of protooncogenes activation Point mutation Chromosomal rearrangement Gene amplification promoter insertion (4) Products and functions of protooncogenes Growth factors: PDGF,FGF, EGF Growth factor receptors Signal- transducing proteins: ras Nuclear regulatory proteins: myc Cell cycle regulatory proteins: cyclins 8.1.2 Tumor suppressor gene 1.Concept: cellular genes that exist in normal cells inhibit normal growth and cause cells to malignant transform when they become inactive. 2. Examples: Rb , p53 , P16,TGF-β, BRCA-1 , BRCA-2 3. mechanism: allele mutation, deletion, methylation 8.1.3 Genes that regulate apoptosis and DNA repair 8.1.4 Telomeres, telomerase and cancer 1.Telomeres shorting is believed to be a clock that counts cell division, is a tumor-suppressive mechanism. 2.Telomerase: Sustain the function of telomeres Absent from most somatic cell Increased activity of it tumor 8.1.5 Molecular basis of multistep carcinogenesis 8.2 Environmental factors and their mechanism 2. Direct-acting agents (1) Alkylatingand acylating agents: anticancer drugs – cyclophosphamide (2) Others arsenic—skin carcinoma chromium—lung carcinoma cadmium—prostate carcinoma nickel—lung carcinoma 8.2.2 Physical carcinogenic factors 1. Ionizing radiation: X-ray, γ-ray related to leukemia , carcinoma of skin, lung, breast,colon. 2. UV: skin carcinoma 3. Others: