牙髓干细胞的迁移模式.doc

Dental pulp stem cells in the paradigm of migration Sidra Fahim, Pan Shuang, Zhang Lin, Niu Yu-mei (Department of Endodontics, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjinag Province, China) Cite this article: Fahim S, Pan S, Zhang L, Niu YM. Dental pulp stem cells in the paradigm of migration. Zhongguo Zuzhi Gongcheng Yanjiu. 2017;21(1): 146-153. doi:10.3969/j.issn.2095-4344.2017.01.026 orcid: 0000-0001-7469-3098(Niu Yu-mei) Abstract BACKGROUND: Continuing characterization of a multitude of signaling pathways associated with migration suggests that modification of migration in dental pulp stem cells can be achieved in a way which suits efficient tissue regeneration. OBJECTIVE: To identify and analyze the published work undertaken regarding different aspects of migration of dental pulp stem cells. METHODS: A PubMed, ScienceDirect (Elsevier), EBSCOhost, Wiley Online Library, MEDLINE, Scholar Universe, PMC and OVID database search was conducted to access the publications spanning over a period of 15 years ranging from the year 2000 to 2015 by two independent reviewers. The keywords used in our search were “dental pulp”, “stem cells”, “migration”, “pulpal injury”. Language preference was set for articles in English language in this research. This search strategy yielded a total of 46 citations from which relevant studies were selected for review according to pre-determined inclusion/exclusion criteria. RESULTS AND CONCLUSION: For the final review process, 38 articles pointing towards major findings determining migratory behavior of dental pulp stem cells under the effect of a variety of biochemical stimuli and dental materials used in clinical work were retrieved. This review article highlights an implication upon usage of dental pulp stem cells for tissue engineering practices. Subject headings: Tissue Engineering; Stem Cells; Dental Pulp; Pulpitis Funding: the National Natural Science Foundation of China, No. 8127113