湖北地区目标人群中大肠癌筛检结果分析.pdfVIP

· 81O· 2007年 11月第 22_眷第 11 November 2007．Vo1．22．No．11 ． 论著 湖北地区目标人群中大肠癌筛检结果分析 陈继贵 张宇星 王倩 柳巍 路直美 聂绍发 陈超 陈华荣 徐俊 杨睿 【摘要】 目的 通过大肠肿瘤序贯隐血筛检方案的实施， 解湖北地区大肠癌的患病率，并对 该方案的应用进行分析。 方法 采用随机整群分层抽样，选取5个筛查点的17 418人作为目标人 群，对其中40岁以上者进行序贯粪隐血试验，对阳性者进一步行肠镜检查；并对符合条件的高危人群 进行粪隐血和肠镜检查。 结果 目标人群17418人，40岁以上者8884人，接受粪隐血试验检查者 2908人。男女比例1：1．1，中位年龄52岁。序贯粪隐血试验阳性者316人，阳性率为10．9％。序贯 粪隐血试验阳性者中124人接受肠镜检查。检出大肠癌5例，检出率 1．6％。Dukes A期和B期 4例，占检出大肠癌的4／5。 结论 湖北地区大肠癌的患病率呈较高水平，序贯粪隐血筛检方案有较 高的有效性和可行性，尤其是在大肠癌的早期防治中。提高受检人群的依从性是未来筛检工作的重 点。 【关键词】结直肠肿瘤；潜血试验；人群监测；小地区分析 The screening program for colorectal cancer by sequential fecal occult blood test in Hubei province CHEN Ji—gui，ZHANG Yu—xing，WANG Qian， ， —mei，NIE Shao-fa，CHEN Chao，CHEN Hua—rong，XUN Jun，YANG Rui．Department ofColorectal Surgery，Wuhan NO 8 Hospital。Wuhan 430030。 China Corresponding author：CHEN Ji—gui，E—mail：chenjigui@sina．com 【Abstract】 Objective To evaluate sequential fecal occult blood test(SFOBT)program f0r the screening of colorectal cancer and detect the prevalence of colorectal cancer in Hubei province．China． Methods In this study，17 41 8 residents were recruited for target population according to random cluster and stratified sampling．The residents aged at 40 years and over received SFOBT．Those with positive test underwent sigmoidoscopy and colonoscopy． Results The target population was 17 418 persons．among which there were 8884 persons who were at the age of 40 and over，and finally 2908 participants received the screening，with a medium age of 52 years old．111e positive rate of SFOBT was 10．9％ (3 16 persons)． Among those 124 participants underwent diagnostic evaluation including flexible sigmoidoscopy and colonoscopy．Colorectal cancer was detected in 5 cases． Conclusion The prevalence of colorectal cancer is on relatively high level in Hubei province．The av