家族性胃癌4个家系的临床分析.pdfVIP

目 录 中文摘要…………………………………………………………………………3 英文摘要…………………………………………………………………………4 引言…………………………………………………………………………6 材料和方法………………………………………………………………………8 结果…………………………………………………………………………9 讨论…………………………………………………………………………15 结论…………………………………………………………………………16 参考文献………………………………………………………………………20 致谢…………………………………………………………………………21 综述…………………………………………………………………………29 3 万方数据 家族性胃癌4 个家系的临床分析 摘 要 目的：总结家族性胃癌家系的临床病理特点，探讨家族性胃癌病因，为家族性胃 癌患者及家族成员的临床处理和健康指导提供依据。方法：收集4 个家族性胃癌 家系的病例资料，分析其发病年龄、病理类型、病变部位等特点。结果：4 个家 系中共有患者14 例，2 个家系累及连续二代人, 9 例病灶位于贲门，5 例病灶位 于胃窦部;平均发病年龄为61.7 岁，其中50 岁前（包括50 岁）发病4 例;14例 患者的病理类型中，10 例为粘液腺癌或低分化腺癌，1 例为高-中分化腺癌，3 例病理类型不详。在这4 个家系中有2 个家系成员患胃良性疾病，2 个家系成员 患胃外恶性肿瘤。结论：家族性胃癌具有发病年龄早，病变部位以近端胃多见， 肿瘤分化差，有肠外肿瘤趋势、预后差等特点。 关键词：家族性胃癌诊断 防治 4 万方数据 Clinical analysis in four gastric cancer pedigrees Abstract Objective: To study the clinicopathological characteristics of familial gastric cancer and explore the pathogeny of familial gastric cancer, so as to evaluate the diagnosis and treatment of this disease. Methods: Fourteen patients from 4 familial gastric cancer families were analyzed. Result: All 14 patients were found in 4 familial gastric cancer families, among which 9 were gastric cardia cancer, while 5 were gastic antrum cancer. And two families transmitted vertically to 2 generations. The median age of confirmed diagnosis was 61.7 years, 4 patients were confirmed diagnosed before 50 years (include 50 years). The pathological type of the 14 pat