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Effect of Chengzai Pill on the L-Type Ca^2＋ Channel Currents of Osteoblasts Pretreated with Methylprednisolone.pdf
Journal of Traditional Chinese Medicine 2007；27(4)：293—298 293
Effect of Chengzai Pill on the L．Type Ca2+Channel Currents of
Osteoblasts Pretreated with Methylprednisolone
Chen Yanping陈燕平 ，Jia Bingshen贾丙申 ，Huang Keqin黄克勤 ，Zhang Wenjie张文杰 ，
Xue Yan薛延 ，Zhou Chongguang周重光 Zhang Wanqiang张万强
，．Wangjing Hospital,China Academy of Chinese Medical Sciences，Beijing 100102，China
2．BeOing Huangcheng Special Hospitalfor Necrosis of Femoral Head,China
3．College of Preclinical Medicine，Jilin University,China
4．Bering Jishuitan Hospital,China
obiective：To observe the effect of the serum containing Chengzai Pill on the L—type voltage—sensitive
calcium channels current fL。VSCCsC)of osteoblastic MC3T3。E l cells pretreated with methylprednisolone
(mPSL)．Methods：A control group，a model g1 ot：p，a low dose group and a high dose group were set up．
The whole cell patch clamp technique was used to rf：,cord L。VSCCsC of 10 osteoblastic MC3T3一E 1 cells
in each group and their peak currents were determined．Results：The peak current of the control group was
0．2284±0．0209 nA：the peak current of the model group was 0．1839±0．0179 nA：decreased bv 19．5％as
compared with the control group(P0．01)；the peak current of the low and high dose groups was 0．2526±
0．0093 nA and 0．267 1±0．0120 nA respectively，increased bv 37．4％ and 45．2％ as compared with the
model group rP0．01)：the difference between the low and high dose groups was P0．05．Conclusion：1．
mPSL inhibits L。VSCCsC of osteoblasts；and 2．The serum containing Chengzai Pill increases L。VSCCsC
of osteoblasts pretreated with mPSL．
Key Words：Patch clamp；Ca2 channel；Chengzai Pill；methylprednisolone；osteoblast
Methylprednisolone rmPSL1 is a synthetic 苁蓉Herba Cistanches Deserticolae)，Xu Duan(续
glucocorticoid hormone with strong anti。 断 Radix Dipsaci)，Huang Qi r黄芪 Radix
inflammatory, immunosuppressive and
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