HER2和p300／CBP在非小细胞肺癌中表达及意义.pdfVIP

山东医药2007年第47卷第36期 HER2和p300／CBP在非小细胞肺癌中 表达及意义 刘汉勇 ，王晓玫 ，单 军 ，彭树松 ，成志强 ，彭全洲 (1暨南大学第二临床学院，广东深圳518020；2深圳市人民医院) [摘要] 目的 检测非小细胞肺癌(NSCLC)组织中HER2和p300／CBP蛋白的表达，并探讨其临床意义。方 法 应用免疫组织化学Evision二步法，检测71例NSCLC患者肿瘤组织和20例正常肺组织标本中HER2和 p300／CBP蛋白表达水平。结果 正常肺组织未见HER2和p300／CBP蛋白过表达，NSCLC中存在HER2和p300／ CBP蛋白过表达，过表达率分别为34％和76％ (24／71，54／71)。肿瘤组织中HER2蛋白表达情况与肿瘤组织学 类型、TNM分期、淋巴结转移情况有相关性(P=0．039、0．003、0．033)，与肿瘤细胞分化程度、性别、年龄未见相关 性。p300／CBP与肿瘤各临床病理参数无相关性。结论 NSCLC患者肿瘤组织中HER2、p300／CBP蛋白过表达。 HER2过表达程度与NSCLC淋巴结转移、TNM分期和组织学类型有相关性。p300／CBP与肿瘤各临床病理参数无 相关性。 [关键词] 肺肿瘤；非小细胞肺癌 ；人表皮生长因子受体2；p300蛋白；环腺苷酸反应元件联结蛋白 [中图分类号] R734．2 [文献标识码] A [文章编号] 1002．266X(2007)36-0027-03 Expression of HER2 and p3OO／CBP in lung cancer and their clinic significances LIU Han一了ongi， WANG Xiao—mei。SHAN Jun。PENG Shu—song， CHENG z —qiang，PENG Quan-zhou。CAI Jin-zhong。HU fin—tao (1 SecondAffiliated Hospital ofJinan University，Shenzhen 518000，P．R．China) Abstract：[Objective]To detect the expression of HER2 and p300／CBP protein in no．small cell lung cancer (NSCLC)and analyze the relationship between their expression and c~nic significance．[Methods]The protein expres． sions of HER2 and p300／CBP in 71 NSCLC tissues and 20 normal lung tissues were by immunochemistry．[Results]The overexpression of HER2 and p300／CBP in normal lung tissue were not found，the protein levels of HER2 and p300／CBP in NSCLC were generally detected with which hish expression of HER2 was detected as 34％ (24／7 1)and 76％ for p300／ CBP(54／71)．111e rate of protein expression in lung adeno·carcinoma was 45．5％ (20／44)while expression rate Was 19．9％ (4／21)in the squamous carcinoma．These differences have statistics meanings(P0．05)．The overexpression rate of lymph transfer group(43．2％，19／44)Was remarkably higher than the group，which has not been transferred as well(18．5％，5／27)．The two groups had conspicuous significance(P0．05)．HER2